Less climate mitigation will increase the spread of fungal pathogens in certain areas, putting more people at risk.

• Novel projections show that in 15 years, if we rely on fossil fuels instead of clean power (scenario of *), we are likely to see the significant spread of certain fungal pathogens in Europe
• Under this scenario, the spread of Aspergillus flavus, for example, could increase by about 16%, putting 1 million more people at risk of infection in Europe. Infections affect the respiratory system, and this fungus infects a broad range of agricultural crops
• The predictions also show that the spread of another fungus, Aspergillus fumigatus, could increase by 77.5% and potentially expose 9 million people in Europe
• This is a concerning trend due to a rise in antifungal resistance and a severe lack of diagnostics and treatment options for fungal infections

In a new study, published on  and funded by , the effects of rising temperatures on infection-causing fungi have been mapped under different climate change mitigation scenarios until the year 2100. Using climate modelling and forecasts, at the University of Manchester and colleagues have mapped how the global distributions of three fungal pathogens (Aspergillus flavus, Aspergillus fumigatus and Aspergillus niger) could be expected to change as a result.

The rise of pathogenic fungi is a real concern and is being driven by climate change. Fungi are incredibly adaptable organisms, with large, malleable genomes that allow them to colonize new geographies and survive as their environment changes.

Dr. Norman van Rhijn said: 青瓜视频淐hanges in environmental factors, such as humidity and extreme weather events, will change habitats and drive fungal adaptation and spread.

青瓜视频淲e青瓜视频檝e already seen the emergence of the fungus Candida auris due to rising temperatures, but, until now, we had little information of how other fungi might respond to this change in the environment.  Fungi are relatively under researched compared to viruses and parasites, but these maps show that fungal pathogens will likely impact most areas of the world in the future. Raising awareness and developing effective interventions for fungal pathogens will be essential to mitigate the consequences of this.青瓜视频�

The maps show that in a fossil fuel dependent economy, as outlined in the IPCC scenario of , the climate will change to become suitable for fungal pathogens to spread to new geographies, with a marked increase in Europe.

The spread of Aspergillus flavus could increase by about 16%, putting 1 million more people at risk of infection from this deadly fungal pathogen in Europe. This fungus is known to cause severe infections and is resistant to many antifungals available.

This is an especially concerning trend as many fungal infections have high mortality rates, partly because of the lack of diagnostics, vaccines and treatment options as well as a lack of awareness of fungal infections. Additionally, as fungi are more similar to humans than other pathogens, developing anti-fungal treatments without toxic side effects is challenging.

The predictions also show that the spread of Aspergillus fumigatus could increase by 77.5% and potentially expose 9 million people in Europe. This is one of the most common fungal pathogens responsible for life-threatening infections in humans and affects the lungs.

Whilst the rise in global temperatures will increase the spread of fungi in Europe, temperatures in Africa could become so high that some fungi will not be able to survive on the continent. Fungi are an essential component to a functioning ecosystem, decomposing plant and animal matter to reintroduce nutrients into the soil. They also contribute to the carbon cycle which regulates the global climate and temperatures.  

Antifungal resistance is also being driven by the use of fungicides in agriculture, which are used to protect crops and support food production. The researchers also looked at the how the changing environment impacts our use of fungicides.

Viv Goosens, Research Manager at Wellcome said: 青瓜视频淔ungal pathogens pose a serious threat to human health by causing infections and disrupting food systems. Climate change will make these risks worse. To address these challenges, we must fill important research gaps. By using models and maps to track the spread of fungi, we can better direct resources and prepare for the future." 

Fungal infections are transmitted through fungal spores in the air we breathe. People with weakened immune systems, co-morbidities and other risk factors are most vulnerable to infections, although fungi could adapt to become more pathogenic due to rising temperatures and could result in more infections in healthy people.

Despite this mounting threat, fungal infections receive little attention or resources. Less than 10% of an estimated 1.5 to 3.8 million species have been described, and a tiny fraction has had their genome sequenced. Wellcome is awarding over 青瓜视频50mn in funding towards fungal research over the next year. 

The study has been published on preprint platform Research Square, available here

It is the first time course providers have been subject to formal quality assurance by the regulator, which took on the responsibility of regulating PAs and Anaesthesia Associates (AAs) , of which overseeing and approving training courses is a key component, in December last year. 

PAs are healthcare professionals who work under the supervision of a senior doctor, such as a hospital consultant or a GP. 

Once they have completed two years of postgraduate training, they perform different clinical duties including taking medical histories, carrying out physical examinations, and developing and managing treatment plans. 

However, they are unable to prescribe medication or request ionising radiation, such as a chest X-ray or a CT scan.

Professor Tony Heagerty, Head of the School of Medical Sciences, said: 青瓜视频淏y handling routine care, follow-ups, and minor procedures, physician associates can improve workflow and reduce waiting times, as well as give doctors the time to focus on more complex cases.

青瓜视频淲e are delighted to receive formal approval by the General Medical Council to teach physician associates to support this valuable addition to the NHS.青瓜视频�

In addition, three Anaesthesia Associate (AA) courses also received approval by the GMC.

Professor Colin Melville, the GMC青瓜视频檚 Medical Director and Director of Education and Standards, said: 青瓜视频淭his is an important milestone in the regulation of PAs and AAs and will provide assurance, now and in the future, that those who qualify in these roles have the appropriate skills and knowledge that patients rightly expect and deserve.

青瓜视频淎s a regulator, patient safety is paramount, and we have a robust quality assurance process for PA and AA courses, as we do for medical schools. We have been engaging with course providers for several years already, and we only grant approval where they meet our high standards.青瓜视频�

From richer biodiversity and benefits for pollinators, to carbon storage in soils, while balancing hay yields for grazing livestock, the study published in by researchers at The University of Manchester and Lancaster University, in collaboration with the Universities of Yale and Bergen, shows that using combinations of different restoration techniques can markedly enhance the restoration of grasslands.

Given many current grassland recovery projects typically only use one type of technique, or 青瓜视频榠ntervention青瓜视频�, in attempts to deliver ecological benefits, the scientists behind the study hope their findings can help boost grassland restoration initiatives across the country and elsewhere,

Grasslands cover nearly 40% of the Earth青瓜视频檚 land surface and serve as important global reservoirs of biodiversity. They also provide a host of other benefits to people, termed ecosystem services, including food production, water supply, carbon storage, soil nutrient cycling, and tourism. Yet these critical ecosystems are increasingly being degraded, especially by overgrazing, heavy use of fertilisers, and climate change. This is undermining their ability to support biodiversity and deliver other benefits, such as carbon storage and nutrient retention.

The team of scientists show that using single restoration interventions often leads to trade-offs among key grassland ecosystem services 青瓜视频� for example the addition of low amounts of fertiliser boosted hay yields for livestock, but suppressed plant diversity. Also, while the addition of a seed mix alone increased plant diversity and pollination, bringing benefits for nature conservation, it did not benefit hay yield or soil carbon storage. They show that using a combination of different techniques delivers better, more balanced ecological benefits than relying on one single type of intervention.

The combined approach to grassland restoration boosted plant diversity, soil health, carbon storage, pollination, flower abundance, and forage production simultaneously, offering a clear path forward for sustainable land management.

The work was based on a long-term grassland restoration experiment set up in 1989 at Colt Park Meadows, in the Yorkshire Dales, northern England. The experiment included a range of commonly used grassland restoration interventions, including the addition of farmyard manure, low-level inorganic fertiliser, a diverse seed mix, and a nitrogen-fixing red clover, which were tested individually and in all possible combinations. Over several years, between 2011 and 2014, the team measured 26 critical ecosystem functions related to hay yield, soil carbon storage, soil nutrient cycling, soil structure, water quality, pollinator visitation, and plant diversity.

Dr Shangshi Liu, the lead author of the paper from The University of Manchester and now based at Yale, said: 青瓜视频淪ingle solutions are rarely enough青瓜视频攚e need landscapes that work on many levels: for climate, for people, and for nature. By layering complementary actions that target different components of the ecosystem, we can restore a broader suite of ecosystem functions青瓜视频攂alancing trade-offs and minimising unintended consequences.青瓜视频�

Professor Richard Bardgett, who initiated the study at The University of Manchester and recently moved to Lancaster, added: 青瓜视频淭hese findings evidence the potential of combining interventions to boost the restoration of degraded grasslands. By combining interventions, such as adding more diverse plant seeds, small amounts of fertiliser, manure and red clover, we show that it is possible to balance hay yields for livestock as well as boosting biodiversity, carbon storage, and wild flower abundance, although each combination will need to be tailored for specific sites. These findings represent a shift from conventional approaches that typically rely on single management interventions.

青瓜视频淚n doing so, they offer a blueprint for land managers and policymakers seeking to deliver multiple benefits from grassland restoration, which aligns the UN Decade on Ecosystem Restoration (2021青瓜视频�2030) that calls for integrated solutions to ecological degradation.青瓜视频�

The researchers also call for further experimentation across different climates and grassland types, alongside policy frameworks that incentivise grassland restoration. Programmes that currently support single interventions for grassland restoration could be restructured to favour integrated approaches that deliver broader ecological returns of benefit to a wider range of land users.

Ben Sykes, Director of the Ecological Continuity Trust (ECT), who work to secure long-term experiments such as Colt Park, said: 青瓜视频淭he Colt Park Meadows long-term grassland restoration experiment, running since 1989, is one of many decades-long ecological field experiments (LTEs) across the UK that are linked via the ECT青瓜视频檚 national register of experimental sites. These latest results from the Colt Park LTE help demonstrate the irreplaceable value of LTEs in providing the real-world scientific evidence needed to promote conservation, biodiversity restoration and future effective and sustainable land management.青瓜视频�

The study was funded by the UK Department of Environment, Food and Rural Affairs and Natural Environment Research Council (NERC), and benefits from long term support from Natural England.

The study青瓜视频檚 findings are detailed in the paper 青瓜视频�Multiple targeted grassland restoration interventions enhance ecosystem service multifunctionality青瓜视频� which has been published by .

DOI: 10.1038/s41467-025-59157-8

In a Wellcome funded study published today (01/05/25) in Science - one of the world青瓜视频檚 leading scientific journals 青瓜视频� the researchers challenge conventional wisdom taught in schools for over 100 years.

Students are currently taught that during cell division, a 青瓜视频榩arent青瓜视频� cell will become spherical before splitting into two 青瓜视频榙aughter青瓜视频� cells of equal size and shape.

However, the study reveals that cell rounding is not a universal feature of cell division and is not how it often works in the body.

Dividing cells, they show, often don青瓜视频檛 round up into sphere-like shapes. This lack of rounding breaks the symmetry of division to generate two daughter cells that differ from each other in both size and function, known as asymmetric division.

Asymmetric divisions are an important way that the different types of cells in the body are generated, to make different tissues and organs.

Until now, asymmetric cell division has predominantly only been associated with highly specialised cells, known as stem cells.

The scientists found that it is the shape of a parent cell before it even divides that can determine if they will round or not in division and determines how symmetric, or not, its daughter cells are going to be.

Cells which are shorter and wider in shape tend to round up and divide into two cells which are similar to each other.  However, cells which are longer and thinner don青瓜视频檛 round up and divide asymmetrically, so that one

daughter is different to the other.

The findings could have far reaching implications on our understanding of the role of cell division in disease. For example, in the context of cancer cells, this type of 青瓜视频榥on-round青瓜视频�, asymmetric division could generate different cell behaviours known to promote cancer progression through metastasis.

Harnessing this information could also impact regenerative medicine, enabling us to better manufacture the cell types needed to regenerate damaged tissues and organs.

Scientists may one day be able to influence the function of daughter cells by simply manipulating their parental cell shape.

Co-lead author Dr Shane Herbert, a senior research fellow at The University of Manchester said: 青瓜视频淭he phenomenon of mitosis - or cell division - is one of the fundamentals of life and a basic biological concept which is taught from school age.

青瓜视频淪tudents learn that when a cell divides, it will generate a uniform spherical shape. Our study, however, shows that in real living organisms, it is not as simple as that.

青瓜视频淥ur research suggests that the shape of the cell before it divides can fundamentally direct whether a cell rounds, and importantly, if its daughters are symmetric or asymmetric both in size and function.青瓜视频�

The scientists used real time imaging to study the formation of blood vessels in 1-day old transparent zebrafish embryos.

Growing blood vessels and other tissues are made of strands of collectively migrating cells.

Each new vessel is led by a special fast-moving cell at the front with slower cells following behind.

When the fast moving 青瓜视频渢ip青瓜视频� cell divided, the study showed, it didn青瓜视频檛 青瓜视频渞ound-up青瓜视频� as expected. In doing so it was able to divide asymmetrically and generate the new fast 青瓜视频渢ip青瓜视频� cell at the front and a slower following cell behind it.

Co-lead author Dr Holly Lovegrove, a lecturer at The University of Manchester said: 青瓜视频淯sing transparent 1-day old zebrafish embryos allows us to study a dynamic process like cell division inside a living organism.

青瓜视频淲e are therefore able to make movies of this fundamental cell behaviour and in doing so reveal exciting new aspects of how tissues grow.青瓜视频�

The team also used a technique using human cells called micropatterning.

Co-First author Dr Georgia Hulmes, a Postdoctoral Research Associate at The University of Manchester said: 青瓜视频淢icropatterning allows us to generate specifically shaped microscopic patches of proteins that cells can stick to.

青瓜视频淭he cells will then take the shape of the patch. This therefore allows us to change the shape of the cells and test how these shapes impact on the subsequent cell division.青瓜视频�

The micropatterning system used by the scientists is called PRIMO by Alv茅ole. This system allowed the scientists  to manipulate cells into different shapes at tiny resolutions of less than a tenth of the width of a human hair. A UV laser is used to burn specific shapes onto a non-sticky surface. Cells are then seeded onto the surface and will only be able to stick down in areas where the UV laser has printed a shape. The cells then spread out into the laser patterned shape and this allowed the scientists to create the precise shape of cell they desire.

• Video shows cells with membrane and nucleus labelled undergoing division, copyright University of Manchester
• The paper Interphase cell morphology defines the mode, symmetry, and outcome of mitosis, is published in Science.

The three-year programme, which will be piloted in the North West before eventually being rolled out across the UK, aims to make the subject more accessible to students from a wider range of backgrounds. The training will be made available at no cost to the teachers or schools.

Economics is currently offered as an A Level subject at just over half of non-selective state schools in England, compared with 90% of selective schools and 82% of independent schools. This partly reflects a shortage of qualified economics teachers 青瓜视频� made worse by very low levels of new teachers choosing to specialise in the subject.

, Vice President and Dean of the Faculty of Humanities at The University of Manchester, said: 青瓜视频淭he teaching, research and development of economics has a long history at The University of Manchester. Our commitment to equity and diversity across our work is paramount, and this initiative, building on the research from FFT Education Datalab, highlights that we still have much to do. We青瓜视频檙e extremely proud to work alongside the Bank of England in producing more teachers of economics.青瓜视频�

, University Academic Lead for Lifelong Learning, Flexible Learning Programme at The University of Manchester, said: 青瓜视频淎t The University of Manchester, we are passionate about creating flexible, lifelong learning opportunities to help individuals, organisations and sectors adapt to an ever-changing world. This collaboration with the Bank of England offers flexible professional learning to bridge the gap in teaching economics. Our first cohort of teachers starts in September with plans to roll the programme out across the UK in the coming years.青瓜视频�

The launch comes as new research commissioned by the Bank of England and carried out by FFT Education Datalab revealed that:

• Economics has become increasingly popular at A Level and undergraduate level over the last decade.
• There are stark regional differences in participation with students in London more than twice as likely to study economics than those in North-West England.
• Students from disadvantaged backgrounds are far less likely to take economics at school or university than their peers.
• Around 70% of those studying economics at school and undergraduate level are male.

Clare Lombardelli, Deputy Governor for Monetary Policy at the Bank of England, spoke at the launch of the research at The University of Manchester. She talked about her own experience growing up in nearby Stockport where she studied economics A Level at a local sixth form college.

She said: 青瓜视频淓conomics is an increasingly popular subject. But it is not available to enough young people across a range of backgrounds.

青瓜视频淎n economics qualification can be a gateway for young people to a highly rewarding career 青瓜视频� both intellectually and professionally. It also gives people a better understanding of how money works 青瓜视频� which is a vital life skill that can benefit all of us.

青瓜视频淲e are delighted to be working with The University of Manchester on this teacher training programme so economics can tap into a broader range of talent and more people can benefit from the opportunities that come from studying economics.青瓜视频�

Gareth Taylor, Head of Professional Development at the Economics, Business and Enterprise Association, which represents economics teachers, said: 青瓜视频淭here is clear evidence that a shortage and unequal spread of teachers with the knowledge and skills to teach economics is impacting the life chances of young people. This much-needed new programme will enable more schools and colleges to offer economics and is an exciting and very welcome development.青瓜视频�

The full report is available to download at

Teachers interested in signing up to the programme are asked to complete an .

36,000 runners took part in the 26.2-mile race which started at Old Trafford football stadium, looping down to Stretford, Sale, Altrincham, Baguley, Sale Moor, Chorlton, Whalley and Hulme before finishing on Oxford Road.

The adidas Manchester Marathon青瓜视频檚 conclusion at The University of Manchester was new for 2025, with the historic university chosen to close off the race in recognition of its buildings青瓜视频� grandeur and its reputation as a hub of innovation and progress.

James Marenghi, Head of Sport & Physical Activity at The University of Manchester said: 青瓜视频淎 huge congratulations to all those who took part in the Manchester Marathon on Sunday, I hope you enjoyed the experience and feeling of achievement as you crossed the finish line. Whilst it was great to get a feel for the atmosphere across the route, it was fantastic to see the thousands of participants and spectators under the iconic University arches at the finish line celebrating their successes.

青瓜视频淎t the University, sport and physical activity is extremely important for our community青瓜视频檚 wellbeing and we are delighted to have supported such a fantastic event that will enable a positive health benefit to our students, staff and local region. We hope that everyone involved is inspired to continue their fitness journey beyond this event and make the most of the other opportunities available through the University to stay active.青瓜视频�

The University was also chosen to backdrop the finish line this year to allow runners a better post-finish experience, with the University perfectly situated among bars, restaurants, shops and transport options.

Members of staff at the University took part in the challenge including James Spearing, Change Communications Officer, who ran to raise money for Breast Cancer UK.

He said after the event: 青瓜视频淚 enjoyed my run today as part of a four-person relay team and raising money for charity. I love having events like this on my doorstep in Manchester.

青瓜视频淲hat made it even better this year was how the new finish line was able to showcase The University青瓜视频檚 beautiful architecture as another iconic location in the city - it青瓜视频檚 not all about Old Trafford!青瓜视频�

Kirsty Wilde, Director of Operations at A.S.O. UK, said: "This year青瓜视频檚 event was truly exceptional, culminating in a breathtaking new finish line on Oxford Road set against the iconic backdrop of the University of Manchester. Welcoming 36,000 participants to the event was a proud moment for everyone involved.

青瓜视频淲e are grateful to The University of Manchester for their ongoing support in helping us to deliver one of Europe青瓜视频檚 largest marathons, and we look forward to building on this and to working with them in the years to come."

The University of Manchester has been at the heart of the city of Manchester for two centuries and it celebrated its bicentenary in 2024.

Key Findings

• Contrary to common belief, and consistent with other recent large-scale studies, loneliness decreases with age. 29% of Gen Z feel lonely compared to 14% of Baby Boomers and the Silent Generation. Yet, most interventions still focus on the elderly 青瓜视频� highlighting a gap for products, services, and workplace cultures that prioritise belonging amongst young people.
• Perhaps surprisingly, more than 50% of people find positive alone time a helpful way of overcoming loneliness 青瓜视频� revealing a powerful opportunity for businesses to design environments, products, and experiences that support solitude, not just social interaction.
• 14% of people who completed the survey say they have nowhere to go when they feel lonely, but want to connect with others 青瓜视频� a clear opportunity for businesses to create connection-friendly spaces in places such as caf茅s, retail stores, and offices.
• 60% report experiencing 青瓜视频榬elational青瓜视频� or 青瓜视频榗ollective青瓜视频� loneliness, not just 青瓜视频榠ntimate青瓜视频� loneliness 青瓜视频� opening the door for brands to design experiences that foster everyday social connection.
• People not belonging to a group are 1.6x more likely to feel lonely 青瓜视频� giving businesses a chance to build community through memberships, loyalty programs, and shared identity experiences.
• Dissatisfaction with income doubles the likelihood of loneliness, regardless of actual earnings 青瓜视频� suggesting companies can drive loyalty and retention among their workforce by improving perceived financial well-being, not just financial status.

The report launch invites purpose-driven business leaders to join the Business vs. Loneliness change platform, working together with public and non-profit partners to help create a more connected world through business.

To access the report and for more information, visit . 

The compound, developed by the scientists and known as caADAMTS13, could be a breakthrough for patients who have brain blood clots with an overabundance of platelets-  the tiny cell fragments that help form clots and are often not treatable by existing therapies. 

The study, funded by a British Heart Foundation 4-Year PhD Studentship Program and The University of Manchester Innovation Factory is published in the leading journal in the field, Stroke. 

It is the first potential new treatment for stroke in the UK since the clotbusting drug recombinant tissue plasminogen activator (rtPA) was licensed in September 2002. 

According to existing research, rtPA is only effective in as few as 10% to 35% of patients and is associated with a significant risk of bleeding. 

Another clotbuster called Tenecteplase (TNK), a variant of rtPA, was recently approved for the treatment of acute ischemic stroke in the United States but has similar limitations to rtPA. 

Both rtPA and TNK have similar efficacy and risk of haemorrhage. 

Von Willebrand Factor (VWF), a protein involved in blood clotting, helps platelets stick to damaged blood vessels and form the structure of blood clots. 

The greater the proportion of platelet and VWF components in a clot, the less effective rtPA is in dissolving it. 

The scientists investigated an alternative strategy which utilises caADAMTS13, an enzyme that reduces the size of VWF and helps break down blood clots. 

In previous mouse studies they have already shown that caADAMTS13 improves cerebral blood flow, reduces damage in the brain, reduces the depositing of both platelets and a clot promoting protein called fibrin, as well displaying anti-inflammatory properties. 

However, until now, a head to head comparison with the existing therapies of rtPA and  TNK had not been carried out. 

The scientists directly compared caADAMTS13 with rtPA and TNK in mice with a cerebral artery blockage from platelet and VWF rich clots, to mimick rtPA-resistance. 

They found that the restoration of cerebral blood flow 1 hour after treatment was the greatest in the mice treated by caADAMTS13 and that at 24 hours the caADAMTS13 mice had reduced brain damage.

Lead author Lucy Roberts, from The University of Manchester, said: 青瓜视频淲hen someone has an acute ischemic stroke, doctors need to quickly remove the clot blocking cerebral arteries in the brain.

青瓜视频淭o avoid  severe and potentially life-threatening complications, the need to act fast is acute. Unfortunately, current treatments are only sometimes effective.

青瓜视频淗owever, our findings show that the compound we developed, called caADAMTS13, is more effective than current stroke treatments

青瓜视频淭hat is why it is tremendously exciting that this compound could one day meet an unmet clinical need for stroke patients.青瓜视频�

Co-author and principle investigator Professor Stuart Allan from The University of Manchester said: 青瓜视频淲e know that removing blood clots can improve outcomes in stroke and that current treatments don青瓜视频檛 always work.

青瓜视频淭herefore, the approach is proven to work and we just need better drugs that can break down all types of blood clots. We think caADAMTS13 may allow this to happen.青瓜视频�

Professor Bryan Williams, Chief Scientific and Medical Officer at the British Heart Foundation, said: "A stroke is a medical emergency. For every minute blood flow to the brain is disrupted during a stroke, millions of nerve cells can become damaged and die. Stroke remains the single biggest cause of severe disability in the UK and we urgently need new treatments.

青瓜视频淢ore research will be needed to understand how these early results in mice can be translated to humans, but this study gives us a promising glimpse into a future where the compound caADAMTS13 could potentially be developed as a new therapy to safely and effectively dissolve blood clots in the brain.青瓜视频�

The paper Comparison of the Novel Thrombolytic Constitutively Active ADAMTS13 With Clinical Thrombolytics in a Murine Stroke Model , DOI: 10.1161/STROKEAHA.125.050848, is available

• The  video animation  illustrates the formation of a clot. Please credit the .
• For the image of the brain, please credit the .

For over 30 years Professor Itzhaki, professorial fellow emerita, University of Manchester and visiting professorial fellow, University of Oxford, has pursued the idea that HSV1, the herpes virus that causes cold sores, is a precursor to the development of AD. 

The 2025 STATUS List features 50 influential people shaping the future of health and life sciences across biotech, medicine, health care, policy, and health tech. 

The list is wide-ranging: from the biotech and health system executives who lead the market, to scientists developing AI technologies and breakthrough therapies, to patient advocates and activists.  

At  the University of Manchester, Professor Itzhaki青瓜视频檚 team discovered that HSV-1 DNA is present in the human brain in a high proportion of older people - the first microbe to be detected definitively in normal human brains.

The researchers later indicated that the virus when in the brain, in combination with a specific genetic factor, confers a high risk of developing AD.

She recently co-authored a that suggested that repeated head injuries could reawaken dormant HSV1 virus in the brain, triggering the onset of the disease.

The research team found that even mild brain trauma can trigger this chain reaction, leading to harmful changes associated with memory loss and cognitive decline.

The idea is winning purchase as the 青瓜视频渁myloid hypothesis青瓜视频� 青瓜视频� which proposes that Alzheimer青瓜视频檚 is caused by a protein buildup in the brain 青瓜视频� loosens its grip on the scientific community.

The researchers hope their work will pave the way for new treatments to protect against neurodegeneration, particularly for those at high risk due to repeated concussions.

Professor Itzhaki said: 青瓜视频淚 am delighted to be included in this year青瓜视频檚 STATUS list. It is a great honour and a recognition that my work is finally being accepted by the scientific community.

青瓜视频淢ost people now accept that dormant Herpes Simplex Virus in the brain  can become reactivated and in so doing can trigger the symptoms of Alzheimer青瓜视频檚 Disease.青瓜视频�

Enzymes are proteins that catalyse chemical reactions, turning one substance into another. In labs, scientists engineer these enzymes to perform specific tasks like the sustainable creation of medicines, and materials. These biocatalysts have many environmental benefits as they often produce higher product quality, lower manufacturing cost, and less waste and reduced energy consumption. But to find 青瓜视频榯he one青瓜视频�, scientists must test hundreds of variants for their effectiveness, which is a slow, expensive, and resource-intensive process.

Research conducted by The University of Manchester in collaboration with AstraZeneca is changing this. The team developed a method for a technique that can test enzyme activity up to 1,000 times faster than traditional methods. The new method, developed over the last eight years and detailed today in the journal  is called DiBT-MS (Direct Analysis of Biotransformations with Mass Spectrometry).

It builds on an existing technology called DESI-MS (Desorption Electrospray Ionization Mass Spectrometry), a powerful tool that allows scientists to analyse complex biological samples without the need for extensive sample preparation. 

By making small adaptations to the technology, the scientists designed a protocol to directly analyse enzyme-triggered chemical reactions, known as biotransformations, in just minutes. The new method can process 96 samples in just two hours青瓜视频攖asks that would previously take days using older techniques.

It has also been optimised to allow the researchers to reuse sample slides multiple times improving testing efficiency and decreasing the use of solvents and plasticware.

The team has already successfully applied this technique to a range of enzyme-driven reactions, including those enzymes particularly valuable in the development of therapeutics.

Looking ahead, The University of Manchester will continue to explore ways to boost partnerships between laboratories and tackle other challenges that often hinder collaboration, such as geographical barriers and limited funding.

This research was partly funded by a UKRI Prosperity Partnership grant in collaboration with AstraZeneca.

Journal: Nature Protocols

Full title: Direct analysis of biotransformations with mass spectrometry青瓜视频擠iBT-MS

DOI: 10.1038/s41596-025-01161-9

Link:

青瓜视频淭he other circumstance for unwanted behaviour was while they were working in their first part-time job as a teenager, with adult male customers making sexual or otherwise inappropriate comments to them while they were working. A young girl working her first job probably isn青瓜视频檛 going to feel able to challenge this behaviour or speak to someone about it.青瓜视频�

Ms McFalone also carried out interviews with affected women. One told her she was 13 years old when she first was 青瓜视频渃at-called in a school uniform青瓜视频� by 青瓜视频渇ully grown men.青瓜视频� Another said: 青瓜视频淚 worked for a pizza place as my first job 青瓜视频� surprisingly the worst sort of male attention I got, which was borderline illegal, was when I was 15.青瓜视频�

The Breakthrough Prize 青瓜视频� popularly known as the 青瓜视频淥scars of Science青瓜视频� 青瓜视频� honours scientists driving remarkable discoveries. 

CERN青瓜视频檚 four major LHC experiment collaborations 青瓜视频� , , , and  青瓜视频� have been recognised for testing the modern theory of particle physics 青瓜视频� the Standard Model 青瓜视频� and other theories describing physics that might lie beyond it to high precision.

In particular, the team have been awarded for discoveries made during the LHC Run-2 data up to July 2024, including detailed measurements of Higgs boson properties, the discovery of new particles, matter-antimatter asymmetry and the exploration of nature at the shortest distances and most extreme conditions.

The University of Manchester researchers are involved in two of the four projects, ATLAS and LHCb. ATLAS is designed to record the high-energy particle collisions of the LHC to investigate the fundamental building blocks of matter and the forces governing our universe in order to better understand building blocks of life, while LHCb focuses on investigating the slight differences between matter and antimatter.

, Head of Physics and Astronomy at The University of Manchester and former leader of the LHCb experiment explained that for his experiment 青瓜视频渢he department constructed a silicon pixel based 青瓜视频榗amera青瓜视频� for the new version of the experiment that takes images 40 million times per second. Members played significant roles in the discovery of new matter antimatter differences and the discovery of new particles青瓜视频�.

The four LHC experiment collaborations involve thousands of researchers from over 70 countries. The $3M award was collected at a ceremony in LA by Parkes青瓜视频� successor as leader of the experiment along with the leaders of the other three experiments.

Following consultation with the experiments青瓜视频� management teams, the Breakthrough Prize Foundation will donate the $3 million Prize to the . The Prize money will be used to offer grants for doctoral students from the collaborations青瓜视频� member institutes to spend research time at CERN, giving them experience in working at the forefront of science and new expertise to bring back to their home countries and regions.

Going forward, the LHC experiments will continue to push the boundaries of knowledge of fundamental physics to unprecedented limits. The upcoming upgrade of the Large Hadron Collider, the High-Luminosity LHC, which many of The University of Manchester青瓜视频檚 physicists and engineers are involved in, aims to ramp up the performance of the LHC, starting in 2030, in order to increase the potential for discoveries.

The researchers suggest that policymakers should increase funding so that deprivation is taken into account as a factor in general practice funding to address income disparities between GPs in more deprived and less deprived areas.

Published in the today (22/04/25) and funded by the , the researchers analysed data from over 8,500 GPs between 2015 and 2021 in the GP work life

They looked at the relationship between deprivation of practice population and job pressures, job satisfaction, reported income, working hours, and intentions to leave direct patient care.

The lead researcher is , an NIHR Clinical Lecturer at The University of Manchester and practicing GP.

He said: 青瓜视频淭his study shows how the socioeconomic deprivation of practice populations in England is adversely linked to the working conditions of the GPs that work there.

青瓜视频淲e highlight a clear and persistent challenge in ensuring equitable healthcare provision.

青瓜视频淲ithout targeted investment and policy interventions, the difficulties faced by GPs in deprived areas will only continue to worsen, exacerbating health inequalities.青瓜视频�

Key Findings also included:

• GPs in the most deprived areas earn less than those in wealthier areas with an average difference of 青瓜视频5,525 less per year.
• Despite higher job pressures, there were no differences in overall job satisfaction, hours worked per week, or intentions to leave patient care between GPs working in more deprived and less deprived areas.

from The University of Manchester, senior author of the study, added: 青瓜视频淭hough deprived populations have higher needs for GP services, we know these areas have the most difficulty recruiting and retaining GPs.

青瓜视频淥ur study is the first to examine how working in deprived areas affects the working lives of GPs. Addressing their concerns about increased job pressure and decreased resources would help reduce health inequalities.青瓜视频�

According to the researchers, the findings explain why working in areas of greater deprivation is less attractive to GPs, exacerbating workforce recruitment and retention issues.

Dr Anderson added: 青瓜视频淎longside financial incentives, non-financial incentives such as enhanced career development opportunities including fellowships that incorporate time for additional training, research, and leadership responsibilities could be a useful lever to promote GP recruitment and retention in areas of greater deprivation青瓜视频�.

青瓜视频淲e also think it青瓜视频檚 important to acknowledge we find no differences in hours worked per week, job satisfaction, and intention to quit direct patient care in more deprived and less deprived areas.

青瓜视频淒espite the challenges experienced by GPs working in areas of greater deprivation, this suggests that there are many rewarding aspects of working in areas of greater deprivation.  A broader recognition by the GP community of the potential advantages of working in areas of greater deprivation would therefore be helpful to promote recruitment and retention.青瓜视频�

This article reports the findings from independent research commissioned by the Department of Health and Social Care and carried out by the Policy Research Unit in Health and Social Care Systems and Commissioning (PRUComm). The research was conducted by the Health Organisation, Policy, and Economics (HOPE) group within the Centre for Primary Care & Health Services Research at The University of Manchester. The study was funded by the National Institute for Health and Care Research (NIHR) Policy Research Programme. The views expressed are those of the authors and not necessarily those of the Policy Research Programme, NIHR, or the Department of Health and Social Care

• Deprivation and General Practitioners青瓜视频� working lives: Repeated cross-sectional study is published in the  Journal of the , DOI: JRSM-24-0273.R2 and is available here.

The study, funded by the Jon Moulton Charity Trust, found that a dose of inhaled beclomethasone -  known as Clenil Modulite庐 or the 青瓜视频榖rown青瓜视频� steroid inhaler in the UK- could lead to better clinical outcomes if taken between 3pm and  4pm.

The study was carried out in the Medicines Evaluation Unit (MEU) at Wythenshawe Hospital with support from both the National Institute for Health and Care Research (NIHR) Manchester Biomedical Research Centre (BRC) and the NIHR Oxford Health BRC.

It is the first to show the effect of coordinating a commonly used asthma treatment with the body's circadian rhythms 青瓜视频� or body clock-  on daily physiological and immunological changes.

It follows on from a 2023 by the research team which  demonstrated enhanced steroid sensitivity in immune cells at 4PM compared to 4AM.

It also supports the theory that the onset of the inflammatory cascade  - a complex series of chemical reactions occurring  within the body leading to inflammation and healing - begins  in the mid-afternoon.

According to Asthma +Lung UK, around 7.2 million Brits have asthma or 8 in every 100 people.

People with asthma suffer from wheezing, breathlessness, and a cough or a tight chest  which are triggered by things like exercise, allergens or changes in weather.

At the moment there is no cure for asthma, though most people with asthma can control their symptoms using asthma inhalers and other medicines.

The study, published in Thorax (16/04/25), was led by Dr Hannah Durrington, Senior Clinical Lecturer and MRC Clinician Scientist at The University of Manchester and honorary consultant physician at Manchester University NHS Foundation Trust , along with Dr Ran Wang, an NIHR Clinical Lecturer, also at the University of Manchester.

Dr Durrington said: 青瓜视频淯p to three quarters of patients experience worsening symptoms overnight and up to 80% of fatal asthma attacks occur at night.

青瓜视频淭his study shows that aligning the timing of beclomethasone 青瓜视频� 青瓜视频榯he brown inhaler青瓜视频� a commonly taken asthma treatment  - with the body clock could have significant impacts on treatment outcomes.

青瓜视频淎nd this occurred without any of the associated adverse effects or costs of taking higher doses of steroids.

青瓜视频淥ur findings warrant further validation in a larger clinical trial to establish clinical feasibility in a real-life setting and to evaluate the health and economic impacts.青瓜视频�

The 21 patients in this cross-over study received the 400碌g dose once-daily between 8AM and 9AM; once-daily between 3PM and 4PM; and 200碌g twice-daily between 8AM and 9AM and between 8PM and 9PM- the 青瓜视频榰sual青瓜视频� pattern of dosing in the UK.

All patients received the three regimes in a randomized order for 28 days, with a 2-week washout period between treatment periods.

The scientists tested lung function and blood eosinophil counts -a key biomarkers for airway inflammation - and serum cortisol levels to assess health outcomes.

The mid-afternoon dose resulted in the largest increase in overnight lung function and a significant  overnight suppression in blood eosinophil counts compared to once-daily morning and standard twice-daily dosing regimes.

Dr Durrington added: 青瓜视频淥ur findings provide key opportunities for novel chronotherapeutic development in asthma, leading to the possibility of tailored therapy based on individuals青瓜视频� preference in timing of drug administration and their biological rhythm in disease.青瓜视频�

The paper The impact of dosage timing for inhaled corticosteroids in asthma: a randomised 3-way crossover trial is published in , DOI/10.1136/thorax-2024-222073

Between 2011 and January of this year, 114 spinout companies were tracked for The University of Manchester in data produced by the Royal Academy of Engineering and Beauhurst.   

There has been a significant rise (32.6%) in the number of Manchester spinouts since the last report, jumping from 86 to 114. Eight additions were due to the revised HESA definition of what constitutes a spinout.  

The University青瓜视频檚 Technology Transfer Office, The University of Manchester , has been at the forefront of spinout generation at the University, helping to bring ideas to life by licensing intellectual property (IP) and making an impact on industry.  

Catherine Headley, CEO of the Innovation Factory, said: 青瓜视频淲ith many years of experience delivering commercialisation from The University of Manchester青瓜视频檚 research and intellectual property, we are proud to play a key role in the University青瓜视频檚 impressive ranking as a top-tier institution for spinout generation.  

青瓜视频淭he Innovation Factory is excited to build on the success of the more than 100 existing spinout companies we have created from the University青瓜视频檚 academic research, driving further innovation and impact for the region and beyond.青瓜视频�   

The report highlighted how the 青瓜视频楪olden Triangle青瓜视频� of Oxford, Cambridge and London, the UK青瓜视频檚 research and development (R&D) cluster, accounts for 27.7% of the total spinout population.   

The University of Manchester fell just behind Imperial College London (132) for number of spinouts, with the University of Cambridge (175) and University of Oxford (225) taking the second and first spots respectively.  

The report also highlighted the top sectors by number of spinouts, with pharmaceuticals (399), data provision and analysis (282) and electronics hardware (269) making up the top three. The highest emerging sectors in this report include artificial intelligence (214), software-as-a-service (180) and CleanTech (169).  

In keeping with Manchester青瓜视频檚 innovation drive, the University of Manchester recently established its new innovation capability, , to connect and catalyse the innovation ecosystem in Manchester and the wider region.  

By making the University青瓜视频檚 world-class research, innovation assets and talent more accessible to all, Unit M is attracting and growing innovation-intensive businesses in the region. It is designed to address all aspects of the innovation challenge 青瓜视频� from R&D and innovation adoption through to talent and skills 青瓜视频� creating an economy that creates good jobs, higher pay, and improved productivity, alongside supporting and nurturing spinout talent.  

Professor Lou Cordwell OBE, CEO of Unit M, said: 青瓜视频淭he University of Manchester has long been the innovation engine of the city, making it no surprise that it has ranked so highly for spinout generation.  

青瓜视频淭his stellar track record has paved the way for Unit M to drive a more inclusive model of innovation-led growth, bridging the gap with other participants in the innovation economy. This outward facing ethos will make the innovation assets and talents of the University more accessible to all - enabling Manchester to fulfil its economic potential and supercharge growth both regionally and nationally.青瓜视频� 

Researchers at The University of Manchester have developed a ground-breaking method to precisely measure the strength of hydrogen bonds in confined water systems, an advance that could transform our understanding of water青瓜视频檚 role in biology, materials science, and technology. The work, published in , introduces a fundamentally new way to think about one of nature青瓜视频檚 most important but difficult-to-quantify interactions.

Hydrogen bonds are the invisible forces that hold water molecules together, giving water its unique properties, from high boiling point to surface tension, and enabling critical biological functions such as protein folding and DNA structure. Yet despite their significance, quantifying hydrogen bonds in complex or confined environments has long been a challenge.

青瓜视频淔or decades, scientists have struggled to measure hydrogen bond strength with precision,青瓜视频� said , who led the study with and Dr Ziwei Wang. 青瓜视频淥ur approach reframes hydrogen bonds as electrostatic interactions between dipoles and an electric field, which allows us to calculate their strength directly from spectroscopic data.青瓜视频�

The team used gypsum (CaSO鈧劼�2H鈧侽), a naturally occurring mineral that contains two-dimensional layers of crystalline water, as their model system. By applying external electric fields to water molecules trapped between the mineral青瓜视频檚 layers, and tracking their vibrational response using high-resolution spectroscopy, the researchers were able to quantify hydrogen bonding with unprecedented accuracy.

青瓜视频淲hat青瓜视频檚 most exciting is the predictive power of this technique,青瓜视频� said Dr Yang. 青瓜视频淲ith a simple spectroscopic measurement, we can predict how water behaves in confined environments that were previously difficult to probe, something that normally requires complex simulations or remains entirely inaccessible.青瓜视频�

The implications are broad and compelling. In water purification, this method could help engineers fine-tune membrane materials to optimise hydrogen bonding, improving water flow and selectivity while reducing energy costs. In drug development, it offers a way to predict how water binds to molecules and their targets, potentially accelerating the design of more soluble and effective drugs. It could enhance climate models by enabling more accurate simulations of water青瓜视频檚 phase transitions in clouds and the atmosphere. In energy storage, the discovery lays the foundation for 青瓜视频渉ydrogen bond heterostructures青瓜视频�, engineered materials with tailored hydrogen bonding that could dramatically boost battery performance. And in biomedicine, the findings could help create implantable sensors with better compatibility and longer lifespans by precisely controlling water-surface interactions.

青瓜视频淥ur work provides a framework to understand and manipulate hydrogen bonding in ways that weren青瓜视频檛 possible before,青瓜视频� said Dr Wang, first author of the paper. 青瓜视频淚t opens the door to designing new materials and technologies, from better catalysts to smarter membranes, based on the hidden physics of water.青瓜视频�

This research was published in the journal Nature Communications.

Full title: Quantifying hydrogen bonding using electrically tunable nanoconfined water

DOI: 

The research was supported by the European Research Council and UK Research and Innovation (UKRI).

The is a world-leading graphene and 2D material centre, focussed on fundamental research. Based at The University of Manchester, where graphene was first isolated in 2004 by Professors Sir Andre Geim and Sir Kostya Novoselov, it is home to leaders in their field 青瓜视频� a community of research specialists delivering transformative discovery. This expertise is matched by 青瓜视频13m leading-edge facilities, such as the largest class 5 and 6 cleanrooms in global academia, which gives the NGI the capabilities to advance underpinning industrial applications in key areas including: composites, functional membranes, energy, membranes for green hydrogen, ultra-high vacuum 2D materials, nanomedicine, 2D based printed electronics, and characterisation.

The University and the Santa Clara-based company have signed a Memorandum of Understanding (MoU), marking a strategic partnership aimed at leveraging the strengths of both organisations to drive advancements in AI applications across multiple sectors, including healthcare, social care, education, and sustainability. 

This collaboration will provide a foundation for joint research projects, academic exchange programs, and curriculum development initiatives that will shape the future of AI-driven solutions.  

Under the terms of the MoU, the partnership will focus on key initiatives, including:  

Research and Development in AI, Robotics, and Automation 青瓜视频� Exploring applications of AI in healthcare, education, and sustainability, including the development of AI-powered robotic solutions such as Fari for elderly care and Senpai for special needs education.   

AI for All Initiative 青瓜视频� Facilitating upskilling and workforce development programs in AI and robotics for healthcare, social care, and education professionals.  

Joint Degree Programs and Curriculum Development 青瓜视频� Establishing specialized programs in AI, robotics, and automation, incorporating theoretical and practical components with hands-on experience using InGen Dynamics青瓜视频� technologies, including Fari, Senpai, and Origami AI.  

Social Care Testbed Collaboration 青瓜视频� Deploying and evaluating AI-driven robotics solutions in real-world environments to improve care delivery and assess the impact of AI in social care settings.  

AI Ethics and Responsible AI Initiatives 青瓜视频� Promoting transparency, accountability, and ethical AI development through collaborative research and policy discussions.  

Global Exchange Programs 青瓜视频� Enabling international knowledge-sharing by connecting students and researchers from the University of Manchester with InGen Dynamics青瓜视频� Futurenauts initiative in India and beyond.  

The collaboration will be overseen by a Steering Committee co-chaired by Professor Andrew Weightman, Professor of Medical Mechatronics the Department of Mechanical and Aerospace Engineering and Arshad Hisham, Founder & CEO of InGen Dynamics. The committee will meet biannually to define strategic roadmaps and identify new areas of mutual interest.  

Mr Hisham, said: 青瓜视频淭his partnership with The University of Manchester is a significant step toward advancing AI and robotics research that has real-world impact.

青瓜视频淏y combining our industry expertise with the academic excellence of Manchester, we aim to accelerate innovation and create transformative AI solutions for global challenges.青瓜视频�  

Professor Weightman added: 青瓜视频淲e are excited to collaborate with InGen Dynamics to drive forward research and education in AI and automation.

青瓜视频淭his MoU will enable us to integrate cutting-edge technology into our programs while fostering innovation that benefits society.青瓜视频�  

#BeeWell is a youth-centred programme led by The University of Manchester, The Gregson Family Foundation and Anna Freud. The #BeeWell survey listens to the voices of thousands of young people in secondary schools every year to understand and improve their wellbeing.

China recently of the world青瓜视频檚 largest hydropower dam, across the Yarlung Tsangpo river in Tibet. When fully up and running, it will be the world青瓜视频檚 largest power plant 青瓜视频� by some distance.

Yet many are worried the dam will displace local people and cause huge environmental disruption. This is particularly the case in the downstream nations of India and Bangladesh, where that same river is known as the Brahmaputra.

The proposed dam highlights some of the geopolitical issues raised by rivers that cross international borders. Who owns the river itself, and who has the right to use its water? Do countries have obligations not to pollute shared rivers, or to keep their shipping lanes open? And when a drop of rain falls on a mountain, do farmers in a different country thousands of miles downstream have a claim to use it? Ultimately, we still don青瓜视频檛 know enough about these questions of river rights and ownership to settle disputes easily.

The Yarlung Tsangpo begins on the Tibetan Plateau, in a region sometimes referred to as the world青瓜视频檚 third pole as its glaciers contain the largest stores of ice outside of the Arctic and Antarctica. A series of huge rivers tumble down from the plateau and spread across south and south-east Asia. Well over a billion people depend on them, from Pakistan to Vietnam.

Yet the region is already under immense stress as global warming melts glaciers and changes rainfall patterns. Reduced water flow in the dry season, coupled with sudden releases of water during monsoons, could intensify both water scarcity and flooding, endangering millions in India and Bangladesh.

The construction of has historically disrupted river flows, displaced people, destroyed fragile ecosystems and increased risks of floods. The Yarlung Tsangpo Grand Dam will likely be no exception.

The dam will sit along the tectonic boundary where the Indian and Eurasian plates converge to form the Himalayas. This makes the region particularly vulnerable to earthquakes, , and .

Downstream, the Brahmaputra is one of south Asia青瓜视频檚 mightiest rivers and has been integral to human civilisation for thousands of years. It青瓜视频檚 one of the world青瓜视频檚 most sediment-rich rivers, which helps form a huge and fertile delta.

Yet a dam of this scale would trap massive amounts of sediment upstream, disrupting its flow downstream. This could make farming less productive, threatening food security in one of the world青瓜视频檚 most densely populated regions.

The Sundarbans mangrove forest, a Unesco World Heritage Site that stretches across most of coastal Bangladesh and a portion of India, is particularly vulnerable. Any disruption to the balance of sediment could accelerate coastal erosion and make the already low lying area more vulnerable to sea-level rise.

The Brahmaputra eventually flows into a region of fertile fields and mangrove forests. Sk Hasan Ali / shutterstock

Unfortunately, despite the transboundary nature of the Brahmaputra, there is no comprehensive treaty governing it. This lack of formal agreements complicates efforts to ensure China, India and Bangladesh share the water equitably and work together to prepare for disasters.

These sorts of agreements are perfectly possible: 14 countries plus the European Union are parties to a , for instance. But the Brahmaputra is not alone. Many transboundary rivers in the global south face similar neglect and inadequate research.

Researching rivers

In our recent study, colleagues and I analysed . We wanted to assess how much academic research there was on each, what themes it focused on, and how that varied depending on the type of river. We found that, while large rivers in the global north receive considerable academic attention, many equally important rivers in the global south remain overlooked.

What research there is in the global south is predominantly led by institutions from the global north. This dynamic influences research themes and locations, often sidelining the most pressing local issues. We found that research in the global north tends to focus on technical aspects of river management and governance, whereas studies in the global south primarily examine conflicts and resource competition.

In Asia, research is concentrated on large, geopolitically significant basins like the Mekong and Indus. Smaller rivers where water crises are most acute are often neglected. Something similar is happening in Africa, where studies focus on climate change and water-sharing disputes, yet a lack of infrastructure limits broader research efforts.

Small and medium-sized river basins, critical to millions of people in the global south, are among the most neglected in research. This oversight has serious real-world consequences. We still don青瓜视频檛 know enough about water scarcity, pollution, and climate change impacts in these regions, which makes it harder to develop effective governance and threatens the livelihoods of everyone who depends on these rivers.

A more inclusive approach to research will ensure the sustainable management of transboundary rivers, safeguarding these vital resources for future generations.

, Leverhulme Early Career Fellow, Geography,
This article is republished from under a Creative Commons license. Read the .

The finding, from CERN's LHCb experiment, which includes scientists at The University of Manchester, provides new understanding of the 青瓜视频榮tandard Model青瓜视频� of particle physics and a new piece in the puzzle to explain how and why matter ended up dominating over antimatter after the big Bang to form the Universe we see today.

The finding was presented at the Rencontres de Moriond conference in La Thuile, Italy, on 24 March and posted on .

Scientists have known since the 1960s that particles have a distinct asymmetry and can behave differently from their antimatter counterparts 青瓜视频� a phenomenon called "CP violation." While this effect has been seen before in the break-up of certain particles, known as mesons,  this is the first time it has been definitively observed in particles similar to those of ordinary matter, known as baryons. Baryons, which include protons and neutrons, make up most of the visible matter in the Universe and consist of three quarks.

LHCb spokesperson Vincenzo Vagnoni, said: 青瓜视频淭he reason why it took longer to observe CP violation in baryons than in mesons is down to the size of the effect and the available data.

青瓜视频淲e needed a machine like the Large Hydron Collider (LHC) capable of producing a large enough number of beauty baryons and their antimatter counterparts, and we needed an experiment at that machine capable of pinpointing their decay products. It took over 80 000 baryon decays for us to see matter青瓜视频揳ntimatter asymmetry with this class of particles for the first time.青瓜视频�

Every particle has an antimatter counterpart with the same mass but an opposite charge. Normally, these pairs should behave like perfect mirror images of each other. However, when particles break down or transform, such as during radioactive decay, this symmetry can be slightly distorted (CP violation). This means that matter and antimatter particles don青瓜视频檛 always decay at the same rate. Scientists can detect and measure this tiny difference using advanced detectors and powerful data analysis techniques.

The LHCb collaboration observed CP violation in a particle called the beauty-lambda baryon (螞b), a heavier, short-lived cousin of the proton. They analysed data from millions of particle collisions collected during two runs of the LHC between 2009 and 2018 in search of a certain decay.

The team discovered that the 螞b and its antimatter partner do not decay into other particles at exactly the same rate 青瓜视频� a difference of about 2.45%. The difference is large enough to exceed the threshold physicists use to confirm an observation of CP violation. Physicists calculate that the odds of such a discrepancy occurring by chance is less than one in three million.

Chris Parkes, Professor of Experimental Particle Physics at The University of Manchester and the former leader of the LHCb collaboration, said: 青瓜视频淲ithout a difference in the behaviour of matter and antimatter there would be not matter in the universe. All the matter and antimatter would have annihilated and the universe today would be made only of light. The LHCb experiment is specifically designed to look at differences between matter and antimatter in the break-up of particles. This is a landmark discovery in these studies, as it is the first time a difference is seen in particles similar to heavy versions of the proton or neutron.青瓜视频�

 The CP violation predicted by the Standard Model is far too small to explain the matter青瓜视频揳ntimatter asymmetry observed in the Universe. This suggests that there may be additional, unknown sources of CP violation that scientists have yet to discover. Finding these is a key goal of research at the Large Hadron Collider and will remain a focus for future experiments.

 LHCb spokesperson Vincenzo Vagnoni, said: 青瓜视频淭he more systems in which we observe CP violations and the more precise the measurements are, the more opportunities we have to test the Standard Model and to look for physics beyond it.

青瓜视频淭he first ever observation of CP violation in a baryon decay paves the way for further theoretical and experimental investigations of the nature of CP violation, potentially offering new constraints for physics beyond the Standard Model.青瓜视频�

The LHCb Collaboration is continuing its studies with the second generation version of the large experimental apparatus, key elements of which were built in the Physics and Astronomy department at the University of Manchester.

Along with Anglia Ruskin University, Birmingham City University, the University of East London and the University of Warwick, The University of Manchester will help with the adaptation of the EmilyTest GBV Charter framework for the English education system and its alignment with the new Office for Students Condition of Registration around harassment and sexual misconduct, which comes into effect as of 1 August 2025.

The Charter has already proved successful in Scotland, with 13 institutions actively engaging and 6 officially awarded.

The Charter is based on five principles: open and learning, educated and empowered, comprehensive and connected, equal and inclusive, and safe and effective.

EmilyTest was founded by Fiona Drouet after the tragic loss of her 18-year-old daughter, Emily, a law student who died by suicide following physical and psychological abuse by a fellow student while living in halls of residence.

Determined that no other victims and survivors are left under supported and at risk, Fiona established the EmilyTest charity which developed the first of its kind GBV Charter for universities and colleges. The Charter sets minimum standards in gender-based violence prevention, intervention and support, and assists institutions in asking if their policies, practices and procedures would have saved Emily青瓜视频檚 life: 青瓜视频榃ould they pass the Emily test?青瓜视频�.

Dr Simon Merrywest, Executive Director for the Student Experience at The University of Manchester said: 青瓜视频淲e are proud to be one of the first English universities taking part in the EmilyTest pilot following its successful run in Scotland.

青瓜视频淯nfortunately, gender-based violence remains a prevalent issue throughout the UK higher education system today, and we will continue to do whatever it takes to keep all of our students safe and protected both on campus and in their residences. Having got to know Fiona through a shared interest in suicide prevention, and hearing her give powerful voice to Emily青瓜视频檚 experiences and the aims of EmilyTest, I had no hesitation in us signing up. 

青瓜视频淲e look forward to taking part in this very worthy initiative, learning from it, and making impactful changes over the next six months and beyond.青瓜视频� 

The University of Manchester has an existing specialist safeguarding team, , who provide holistic, trauma-informed support to students who have experienced any form of gender-based violence, harassment or hate. The Advice and Response team is made up of specialist caseworkers who provide confidential, practical, and emotional support to students directly and signposting to statutory and other services.

The University has made campus safety a key priority, adopting the SafeZone app in recent years to allow for faster potential response times when urgent help is required on campus or in the city. The SafeZone app can be used to 青瓜视频榗heck in青瓜视频� at any time of the day, quickly and discreetly call for assistance, and get medical help quickly.

The University of Manchester has also partnered with its Students青瓜视频� Union to provide sexual violence support drop-in sessions which are open to anyone looking for support.

Funded by the Biotechnology and Biological Sciences Research Council (BBSRC), the study on mice shows that the brain青瓜视频檚 hypothalamus controls how the immune system adapts during fasting, through a handful of highly specialized neurons responsible for making animals hungry.

Published today (04/04/25) in 青瓜视频攐ne of the world青瓜视频檚 leading immunology journals青瓜视频攖he study shows the brain青瓜视频檚 perception of hunger or fullness, rather than actual eating or caloric restriction, is enough to drive changes in the body青瓜视频檚 immune cells.

The findings cast doubt on the current view that a lack of nutrients alone controls how the immune system responds to fasting, indicating the brain has a critical role, beyond the simple absence of food.

By artificially switching on specific brain neurons in mice青瓜视频攚hich typically signal low energy levels青瓜视频攕cientists induced a synthetic sense of hunger. Remarkably, within hours, they saw a fast reorganization of immune cells in the blood, with a noticeable drop in inflammatory monocytes. These artificially hungry mice looked, from an immune perspective, just like mice that had fasted for real.

This discovery could have important implications for developing new therapies to treat a range of inflammatory diseases as well as for treating wasting syndromes seen in cancer, in which individuals lose weight despite eating normally.

It may also explain why obesity often accompanies inflammatory conditions and why malnourished individuals are more prone to infections and inflammation.

The lead senior researcher, Dr Giuseppe D青瓜视频橝gostino, who coordinated the study, said: 青瓜视频淥ur perceptions can shape our bodies in ways we don青瓜视频檛 always notice. It青瓜视频檚 easy to see how thoughts guide our actions, but this study reminds us that even our internal body adjustments that are not under conscious control respond to the brain青瓜视频檚 signals.

青瓜视频淭his study underlines how important the brain is in regulating the immune system. But if internal or external factors alter the brain青瓜视频檚 perception, these processes can go awry, reminding us how deeply the mind and body are青瓜视频攁nd should remain青瓜视频攃onnected.

"In addition to BBSRC who funded the work, we are grateful to the Medical Research Council for providing early-stage seed funding that helped the lab explore completely novel areas 青瓜视频� a small but truly visionary contribution that still resonates today."

Collaborator and Manchester immunologist Professor Matt Hepworth added: 青瓜视频淭his work challenges the long-standing view that fasting青瓜视频檚 immunological impact is driven purely by nutrient levels. It highlights the nervous system青瓜视频檚 profound influence on how the immune system adapts during fasting.青瓜视频�

Lead author Dr Cavalcanti de Albuquerque said: 青瓜视频淏y showing how the brain exerts top-down control over immune cells, we can further explore when and how fasting might deliver health benefits. It also opens up potential ways to treat infectious, inflammatory, metabolic, and psychiatric conditions.青瓜视频�

The paper Brain Sensing of Metabolic State Regulates Circulating Monocytes   is available

Professor Cinzia Casiraghi has been appointed as Chief Scientific Officer (CSO) at the Graphene Engineering Innovation Centre (GEIC), bringing with her more than two decades of pioneering research experience in graphene and 2D materials.

Since the early 2000s, Professor Casiraghi has been at the forefront of the graphene journey. From identifying the optical fingerprint of graphene to engineering ink-jet printable 2D materials for use in electronics and biomedical applications, her work has paved the way for the development of functional, scalable applications that are now becoming reality across industries.

Casiraghi青瓜视频檚 appointment marks a new chapter for the GEIC, which sits at the heart of the Graphene@Manchester ecosystem. As CSO, she will provide strategic scientific leadership to strengthen the Centre青瓜视频檚 role as a world-leading facility for the translation of 2D materials research into commercial products and technologies. 

She will play a key role in connecting academic expertise with industrial needs, supporting collaborative research at higher Technology Readiness Levels (TRLs), and steering the scientific direction of GEIC projects.   

Her research group at The University of Manchester has led groundbreaking work in Raman spectroscopy of carbon-based nanomaterials, and 2D material ink formulation, with an emphasis on industry-funded projects. Her contributions to printable electronics, ranging from photodetectors, transistors and memories printed onto low-cost and biodegradable substrates, such as paper, have significantly advanced the field. Casiraghi is also a prominent advocate for cross-disciplinary research, building bridges between chemistry, physics, materials science, and engineering.

Professor Casiraghi said:

青瓜视频淚t is an exciting time for 2D materials. I am honoured to take on the role of Chief Scientific Officer at the GEIC. For the past 20 years, I have been dedicated to graphene and 2D materials research, witnessing remarkable progress along this journey. Two decades ago, I was looking at tiny graphene flakes, produced by mechanical exfoliation, with the aim to identify their optical fingerprint.

青瓜视频淭oday, academics and companies regularly use this framework to identify graphene. Today, we have graphene and 2D material inks that can be printed onto paper and plastic to create functional devices, or can be combined with other materials to enhance specific properties. Today, we have well-established methods for large-area deposition of graphene and 2D materials, paving the way for their integration into next-generation electronics.

青瓜视频淚 look forward to driving innovation, advancing our research capabilities, and working alongside the team at the GEIC and the academic community to develop cutting-edge solutions. By fostering collaboration between academia and industry, we aim to demonstrate the value of 2D materials and their transformative potential.青瓜视频�

James Baker, CEO of Graphene@Manchester, said:
青瓜视频淐inzia has been a driving force in the field of graphene and 2D materials research for over two decades, and her appointment as Chief Scientific Officer marks a significant development opportunity for the GEIC. Her depth of expertise, combined with a passion for innovation and collaboration, will ensure we continue to bridge the gap between fundamental science and real-world application.

青瓜视频淎s the GEIC evolves to meet the challenges of a fast-moving innovation landscape, Cinzia青瓜视频檚 leadership will help accelerate our mission to deliver sustainable, scalable technologies that make a meaningful impact across industry sectors.青瓜视频�

As CSO, Professor Casiraghi will work across the GEIC青瓜视频檚 ecosystem 青瓜视频� including academic departments, the National Graphene Institute (NGI), and the wider university research community 青瓜视频� to ensure alignment of scientific vision with industrial ambition. She will lead a team of Theme Leads, drawn from disciplines including materials science and physics, to guide project direction, advise on research outcomes, and lower the barrier between industry and academia.

The role also includes high-level engagement with strategic partners and national innovation stakeholders, helping to position the GEIC as a key player in addressing global challenges around clean growth, mobility, and sustainable development. Casiraghi will support the evaluation of major project proposals, mentor scientific staff, and champion excellence in research infrastructure, collaboration, and impact.

Professor Casiraghi has held academic roles at The University of Manchester since 2010 and currently serves as Chair of Nanoscience and Head of Materials Chemistry in the Department of Chemistry. She previously held research fellowships in Berlin and Cambridge and holds a PhD in Electrical Engineering from the University of Cambridge.

With this appointment, The University of Manchester continues to reinforce its commitment to translating cutting-edge research into real-world impact, supporting the advancement of graphene and 2D materials through collaborative innovation and industrial engagement.

For years, nature has been blamed as a blocker of economic growth. After some ministerial about not letting get in the way of growth ambitions, the UK government released more details of its plans to .

The centrepiece of its aspirations to balance both nature and economic growth is a , to be set up in England through changes to habitat regulations. This should allow developers to stay within their legal obligations towards nature through a payment scheme without delaying their projects.

The is that, as an alternative to relocating important species or improving habitats on the site of a proposed development, a developer could pay into the nature restoration fund. This would pay for larger, more strategically located schemes to protect the species in question.

The fund simplifies and streamlines the regulations while collecting funds to promote more, bigger, better and increasingly .

Protecting nature is not just about bats and newts. According to trade association the Home Builders Federation (HBF), there are 160,000 homes being delayed by what are known as measures. These rules were a response to growing public concerns about land and water pollution caused by nutrient loads 青瓜视频� pollutants such as nitrogen and phosphorus 青瓜视频� associated with livestock farming and spillages from sewage works.

Government agency 74 local authorities that they should not allow any more house building in their areas unless this pollution could be mitigated. But this has led to lengthy and expensive project-by-project reviews to identify potential damage.

How will a fund help?

The fund will build on some schemes that are already known to work. One such scheme works for the protection of . Another successful scheme is project, working to protect and enhance heathland sites where rare birds such as nightingales breed. Crucially, this scheme allows new development to go ahead in adjacent areas.

The fund will be run by Natural England, which aims to draw on these experiences to unblock development at a large scale rather than at single-site level, pooling contributions from developers to pay for mitigation measures when there is a risk to nature.

If a particular 青瓜视频渂locking青瓜视频� issue is identified, experts from Natural England will produce a plan, which must be approved by the environment secretary. A levy on developers will then pay for mitigation measures 青瓜视频渋n perpetuity青瓜视频� (often 30 years), allowing the development to get under way.

Environmental experts have the general principles and approach of the nature restoration fund. But there has also been about whether the plan is well enough thought through. There are also questions on how well it will integrate with other schemes.

A widespread worry is for the future of 青瓜视频� which includes measures for creating and improving using biodiversity units, effectively a form of 青瓜视频渘ature market青瓜视频�. This approach sets a target of 10% for biodiversity improvement based upon the combined distinctness, condition and significance of affected habitats over the lifetime of the development. But these measures are only just .

The concern is that providers of sites for these habitat banks 青瓜视频� which might be councils, landowners, charities or private businesses, for example 青瓜视频� might get cold feet and if they can青瓜视频檛 be certain that their plans will be compatible with the nature restoration fund.

There is concern, too, about how payments from the nature restoration fund would be calculated. These will need to be locally appropriate and not pit nature restoration and biodiversity net gain against each other if, for example, landowners are forced to choose a particular scheme for their land that they are then . With two parallel systems in play, the relationship between them must be crystal clear, otherwise shared goals could be missed.

Another question is whether Natural England can be both regulator and financial beneficiary of the new scheme. There have been calls from some of those already involved in nature markets for some form of .

And it will also be vital that the new scheme respects what青瓜视频檚 known as the 青瓜视频渕itigation hierarchy青瓜视频�. This hierarchy aims to avoid, reduce and then mitigate any impacts on nature on-site in that order. Then developers should consider off-site measures in areas where there could be greater .

But a danger here is that this could disconnect people from nature even further by mitigating ecological loss miles away from the site of the damage. This disconnection is considered to be a critical underlying cause of .

There is much to like about the nature restoration fund, but there is a risk that little will be achieved without the government showing genuine ambition and allocating enough money and staff to properly monitor and enforce it over the long term. Only time will tell whether it achieves the government青瓜视频檚 goal of speeding up development.

At the moment, it is not clear how the fund will complement similar schemes and there is a danger of creating a complex patchwork in nature restoration funding. But if it works well, it could provide a richer funding ecosystem for nature recovery 青瓜视频� a much-needed boost for England青瓜视频檚 nature-depleted landscape.

, Professor, Urban and Environmental Planning and , Senior Lecturer in Planning and Environmental Management
This article is republished from under a Creative Commons license. Read the .

The findings, published in the journal ,  show that these powerful flows could be capable of traveling at speeds of up to eight meters per second, carrying plastic waste from the continental shelf to depths of more than 3,200 meters.

Over 10 million tonnes of plastic waste enter the oceans each year. While striking images of floating debris have driven efforts to curb pollution, this visible waste accounts for less than 1% of the total. The missing 99% 青瓜视频� primarily made up of fibres from textiles and clothing 青瓜视频� is instead sinking into the deep ocean.

Scientists have long suspected that turbidity currents play a major role in distributing microplastics across the seafloor 青瓜视频� The University of Manchester were among the first to demonstrate this through their research on 青瓜视频楳icroplastic Hotspots青瓜视频� in the Tyrrhenian Sea, published in the journal . However, until now, the actual process had not been observed or recorded in a real-world setting.

The latest study conducted by The University of Manchester, the National Oceanography Centre (UK), the University of Leeds (UK), and the Royal Netherlands Institute for Sea Research provides the first field evidence showing the process.

The findings pose a significant threat to marine ecosystems and highlight the urgent need for stronger pollution controls.

Dr Peng Chen, lead author on the study at The University of Manchester, said 青瓜视频淢icroplastics on their own can be toxic to deep-sea life, but they also act as 青瓜视频榗arriers青瓜视频� transferring other harmful pollutants such as PFAS 青瓜视频榝orever chemicals青瓜视频� and heavy metals, which makes them an environmental 青瓜视频榤ultistressor青瓜视频� which can affect the entire food chain.青瓜视频�

The research focused on Whittard Canyon in the Celtic Sea, a land-detached canyon over 300 km from the shore. By combining in-situ monitoring and direct seabed sampling, the team were able to witness a turbidity current in action, moving a huge plume of sediment at over 2.5 metres per second at over 1.5 km water depth. The samples directly from the flow revealed that these powerful currents were not only carrying just sand and mud, but a significant quantity of microplastic fragments and microfibres.

Further analysis found that the microplastics on the seafloor are mainly comprised of fibres from textiles and clothing, which are not effectively filtered out in domestic wastewater treatment plants and easily enter rivers and oceans.

, Geologist and Environmental Scientist at The University of Manchester, who designed and led the research, said: 青瓜视频淭hese turbidity currents carry the nutrients and oxygen that are vital to sustain deep-sea life, so it is shocking that the same currents are also carrying these tiny plastic particles.

青瓜视频淭hese biodiversity hotspots are now co-located with microplastic hotspots, which could pose serious risks to deep-sea organisms.

青瓜视频淲e hope this new understanding will support mitigations strategies going forward.青瓜视频�

Dr Mike Clare of the , who was a co-lead on the research, added: 青瓜视频淥ur study has shown how detailed studies of seafloor currents can help us to connect microplastic transport pathways in the deep-sea and find the 青瓜视频榤issing青瓜视频� microplastics. The results highlight the need for policy interventions to limit the future flow of plastics into natural environments and minimise impacts on ocean ecosystems.青瓜视频�

The study team are now focussing on efforts to better understand the effect that microplastics have on marine organisms, for example sea turtles and deep-sea fauna.

This research was published in the journal Environmental Science and Technology.

Full title: Direct evidence that microplastics are transported to the deep sea by turbidity currents

DOI:

The study of 15.7 million patient records, funded by the National Institute for Health and Care Research and published in the prestigious Journal of the R, implies there could be scope to prescribe far fewer antibiotics. 

The researchers found the probability of being prescribed antibiotics for a lower respiratory tract or urinary tract infection was unrelated to hospital admission risk. 

And the probability of being prescribed an antibiotic for an upper respiratory tract infection was only weakly related to hospital admission risk. 

The study also showed that patient characteristics such as age and the presence of other health problems were only weakly associated with the probability of being prescribed an antibiotic treatment of common infection. 

The most elderly patients in the sample were 31% less likely than the youngest patients to receive an antibiotic for upper respiratory infections. 

That inevitably means, say the researchers, that because many younger people are being prescribed antibiotics, even though they are often fit enough to recover without them, potentially  leading to resistance. 

Conversely,  many older people may not be able to deal with infections without antibiotics are not  receiving them, with the potential of complication and hospital admissions. 

Patients with combinations of diseases were 7% less likely than people without major health problems  to receive an antibiotic for upper respiratory infections. 

Lead authors are  Professor Tjeerd van Staa and Dr Ali Fahmi, from The University of Manchester. 

Professor Tjeerd van Staa said: 青瓜视频淎ntibiotics are effective in treating bacterial infections, but they carry the risks of antimicrobial resistance (AMR) and loss of effectiveness when used inappropriately. 

青瓜视频淭hat is why AMR to antibiotics has been recognised as one of the biggest threats to global public health. 

青瓜视频淕iven the threat of resistance, there is a need to better target antibiotics in primary care to patients with higher risks of infection-related complications such as sepsis. 

青瓜视频淏ut this study finds that antibiotics for common infections are commonly not prescribed according to complication risk and that suggests there is plenty of scope to do more on reducing antibiotic prescribing.青瓜视频� 

The study also showed that the probability of being prescribed an antibiotic for lower respiratory infections was even more unrelated to complication risk during the pandemic, however they were only minor changes for urinary tract infections. 

The research team accessed anonymised patient-level electronic health records of primary care data from The Phoenix Partnership (TPP) through OpenSAFELY, a secure platform for electronic health records in the NHS. 

They included adults registered at general practices in England from January 2019 to March 2023 diagnosed with upper respiratory, lower respiratory and urinary tract infections. 

Patient-specific risks of infection-related hospital admission were estimated for each infection using risk prediction scores for patients who were not prescribed an antibiotic. 

Dr Ali Fahmi added: 青瓜视频淩ather than imposing targets for reducing inappropriate prescribing, we argue that it is far more viable for clinicians to focus on improving risk-based antibiotic prescribing for infections that are less severe and typically self-limiting. 

青瓜视频淧rognosis and harm should explicitly be considered in treatment guidelines, alongside better personalised information for clinicians and patients to support shared decision making.青瓜视频�

青瓜视频淎 Knowledge Support (KSS) led by Professor Tjeerd van Staa, which provides personalised information to clinicians is  now being tested in the North-West England

青瓜视频淲e hope it could provide a workable solution to the problem of untargeted antibiotic prescribing.青瓜视频�

Antibiotics for common infections in primary care before, during and after the COVID-19 pandemic: cohort study of extent of prescribing based on risks of infection-related hospital admissions  is published in  DOI: 10.1177/01410768251328997

The study team at Manchester University NHS Foundation Trust (MFT) and The University of Manchester (UoM) implemented the new technology across MFT hospitals in December 2023, which provides specialist liver care to the Greater Manchester region. The technology aims to improve early detection of hepatocellular carcinoma (HCC) 青瓜视频� the most common cancer affecting the liver and the third most common cause of cancer death.

Developed by Roche Diagnostics, the pioneering test, known as Elecsys庐GAAD, combines blood tests with gender and age, which can increase the detection rate of HCC at an early, curable stage. This is being used alongside routine surveillance tests to see how it can benefit patients, so they have the best chance of surviving this type of cancer.

One of the risks for developing HCC is a pre-existing liver disease and scarring of the liver, known as cirrhosis. Approximately 3,000 people are found to have HCC in the UK every year. Less than 1,000 are identified at a stage when they can have curative treatment, leaving over 2,000 people per year with a cancer that cannot be cured.

More than 600 patients with cirrhosis have been tested using Elecsys庐GAAD within clinics at Manchester Royal Infirmary, Wythenshawe Hospital and North Manchester General Hospital, all part of MFT, and four patients have been detected with early-stage liver cancer at a treatable stage, which would not have been found without the new technology.

Gerry青瓜视频檚 story

Father of three, Gerry, 67 was diagnosed with hemochromatosis approximately 15 years ago, a hereditary condition where the body stores too much iron, which has led to scarring on his liver, cirrhosis.

Whilst attending his routine screening appointment at Wythenshawe Hospital, Gerry joined the research trial using the Elecsys庐GAAD technology, which detected the early stages of liver cancer.

Following a number of CT scans at Manchester Royal Infirmary, it was confirmed that there is a small tumour on the upper part of his liver, which he has now had removed and remains cancer free.

Gerry said: 青瓜视频淚 was shocked to find out that I had liver cancer, but also relieved that it had been found early and it hadn青瓜视频檛 spread any further. I didn青瓜视频檛 have any symptoms that would make me think that there was anything wrong, so I am grateful that the cancer has been caught early, where a number of treatment options are available to me.

青瓜视频淚t isn青瓜视频檛 until you青瓜视频檙e in this position, that you truly realise how cancer can affect anyone, and detecting it early can save your life. I would encourage others to take part in this research trial, if given the opportunity, as this new technology will save lives. I am grateful to be in a position where curative treatment is available and I am now cancer free.青瓜视频�

How the technology works

In early, curable stages, HCC can have no symptoms and so it is recommended that everyone with known cirrhosis is tested every six months which involves an ultrasound scan and a blood test (alpha fetoprotein 青瓜视频� AFP) to screen for primary liver cancer 青瓜视频� HCC.

The new test is an algorithm used in addition to the current standard of care, which uses the AFP information alongside another blood test (Elecsys庐PIVKA-II), age and gender to calculate a risk score. Data suggests that this test increases the likelihood of detecting liver cancer at an earlier stage where curative treatments are far more likely. 

Principal Investigator for the study, Dr Varinder Athwal, Consultant Hepatologist at MFT and Honorary Senior Lecturer at the University of Manchester, said: 青瓜视频淢anchester has some of the highest rates of liver disease and liver cancer in the UK and far too many people are diagnosed when curative treatment is not possible.

青瓜视频淭his innovation is a non-invasive test that easily fits into our current pathway. Early results from the project are very promising and show we are able to detect more cases of HCC at earlier, treatable stages which would have been missed by standard routine care 青瓜视频� so it truly has the potential to save lives.

青瓜视频淯sing this new test and with additional improvements to the surveillance pathway, we believe more than 1,000 people per year could be additionally detected at an earlier stage when their cancer is potentially curable. This number could be increased if more people are offered the test and stay in surveillance, which is something we are addressing in this project.青瓜视频�

Vic青瓜视频檚 story
 

Vic joined the research trial at MFT and was detected in the early, curable stages of liver cancer and despite not being fit enough for common therapies to cure his cancer, Vic has since received a treatment called transarterial chemoembolisation (TACE) which cuts off the tumour青瓜视频檚 blood supply with little or no effect to liver functioning.

Detecting his cancer early through Elecsys庐GAAD means that it has prevented the spread of his cancer and there is currently no sign of his cancer on repeat scans.

He said: 青瓜视频淲hen I agreed to join the trial, I had been being monitored routinely because of the presence of liver disease but the last thing that I thought I would ever develop was cancer. I had been stable for some years and had not experienced any new symptoms to suggest anything had changed.

青瓜视频淭he GAAD test changed all that. The results were high and detected that I had a primary liver cancer which turned out to be a Stage 2 liver cancer. I had no symptoms. I was referred immediately for expert treatment.

青瓜视频淏ecause the GAAD test detected the cancer early I have been able to access one of several treatment options quickly, before the cancer had the chance to spread outside the liver. Early diagnosis and treatment has meant that I can also benefit from the care and support of an amazing multidisciplinary team.

青瓜视频淚t has also meant that I have been given time to involve my family, especially my children, to navigate this journey together. Without the GAAD test, the diagnosis of cancer may have come too late for all of us.青瓜视频�

Through the study, researchers aim to find out if the Elecsys庐GAAD test reduces unnecessary further scans and if it improves earlier detection of HCC. They will also investigate if a six-monthly ultrasound adds any further benefit to Elecsys庐GAAD to detect HCC 青瓜视频� or if Elecsys庐GAAD could be used on its own, which would provide a considerable cost saving to the NHS and a significant improvement to current standard of care. 

Director of Access and Innovation at Roche Diagnostics UK and Ireland, Chris Hudson said: 青瓜视频淩oche Diagnostics is committed to early disease diagnosis and to ensuring our innovations reach the people who need them. Working with the team in Manchester, we are taking the learnings from this hugely successful trial to help other NHS Trusts implement the Elecsys庐GAAD digital diagnostic solution and enable more patients with liver cancer to access timely diagnostics and potentially curative treatments.青瓜视频�

Dr Katherine Boylan, Director of Innovation at MFT said: 青瓜视频淎s one of the largest NHS trusts in the country, MFT is uniquely placed to test the innovation, which brings together the knowledge and expertise of academic, medical and industry partners 青瓜视频� strengthening our position as a leader in research and innovation in the UK. We are proud to partner with Roche Diagnostics to address this unmet clinical need for the benefit of our patients, which has the potential to revolutionise early cancer diagnosis for HCC.青瓜视频�

Elecsys庐GAAD was fast-tracked into the NHS at MFT, following 青瓜视频1million funding from NHS England, to test the accuracy and benefits of technology over a two-year period.

Project Managers at NHS England visited MFT alongside Roche Diagnostics, to see the progress of the project and how we are utilising the test alongside current pathways.

Dr Michael Gregory, Regional Medical Director for NHS England 青瓜视频� North West, said: 青瓜视频淭his is a great example of how the NHS can transform health outcomes and save lives through the use of cutting-edge technology and a greater focus on prevention.

青瓜视频淭he stories of the patients who have already benefited from this new test highlight why it is so important that we diagnose and treat cancers at the earliest possible opportunity and I青瓜视频檓 excited to see how it could be made more widely available in the future.

青瓜视频淚n the meantime, I would continue to encourage people with potential signs of cancer to come forward and speak to their general practice as soon as possible.青瓜视频�

The study is running until April 2025, recruiting more than 600 patients to the research project. Findings from the implementation at MFT will be used to co-develop a plan for the national roll out within the NHS.

This work is supported by Imperial College London who are observing the economic impact of the new technology on the NHS, and Unity Insights who are carrying out an independent evaluation of the findings across the project.

Photo: Photo: Patrick Ezean (NHS England Cancer Programme Manager), Emily Corser (NHS England Cancer Programme Manager), Dr Varinder Athwal (Principal Investigator for the study), Darren Banks (MFT Interim Deputy Trust Chief Executive), Chris Hudson (Roche Diagnostics UK and Ireland), Delphine Scokaert (Roche Diagnostics UK and Ireland), Oliver Street (Programme Manager, The University of Manchester), Dr Katherine Boylan (Director of Innovation at MFT), Laura Tornatore (Senior Programme Manager, LGC).

Ali Oliver MBE, Chief Executive at Youth Sports Trust said:  
 
"At the Youth Sport Trust, we know a child's wellbeing is the foundation for their success, both in and out of the classroom, and physical activity including PE, sport and play is vital to their physical, social, and emotional development. When children are healthy and happy, they are ready to learn. It青瓜视频檚 encouraging to see through these results more parents are recognising the critical link between wellbeing and academic and personal development, with many now prioritising it when choosing a secondary school. We believe measuring wellbeing can help track progress as well as ensuring support is targeted towards those with the greatest needs. 

青瓜视频淭hrough our development of the Well School and Well School Trust movement, a growing collection of schools and trusts taking positive action to improve education outcomes by supporting the health and happiness of their staff and pupils, we are committed to helping make this a reality. In June, we青瓜视频檙e introducing a free Well check service for schools which will help parents easily identify schools committed to nurturing wellbeing, while also supporting schools in creating environments where every young person can thrive physically, mentally, and emotionally."  

Ben Levinson OBE, executive headteacher at Kensington Primary School and chair of the Well school collective, said:

"As a parent, headteacher and chair of the Well School Collective, I have always been a strong advocate for prioritising children's wellbeing within schools. Supporting positive mental and physical health has been at the heart of my approach at Kensington Primary School, and I青瓜视频檓 proud to say that this focus has played a key role in our Outstanding Ofsted grade. By establishing strong wellbeing practices in primary schools, we help parents see the importance of continuing this focus as they look ahead to secondary education. Wellbeing and school excellence are not competing priorities; they are complementary, essential elements that drive success. That is why it青瓜视频檚 so encouraging to see more parents recognising this; when we support wellbeing, we青瓜视频檙e creating the conditions for every young person to flourish, and it青瓜视频檚 vital that schools and parents work together to make this a priority." 

The experts also say that investing in wellbeing is not just a moral imperative - it also makes economic sense. They point to research from  which highlights the substantial financial benefits of prioritising wellbeing, estimating that tackling low wellbeing among young people could deliver billions  
 
To find out more about the national wellbeing measurement programme campaign, visit .  

Led by Health Innovation Manchester, the University of Manchester and Manchester University NHS Foundation Trust, this collaborative project has helped bridge the gap between research and clinical implementation of advanced diagnostic technologies.

ADA is one of ten projects funded within the Greater Manchester portfolio of the Innovation Accelerator (IA) programme, which is transforming the innovation landscape in the UK and paving the way for the future of place-based research and development (R&D) investment.

Since its launch, the IA programme has invested 青瓜视频100m in 26 transformative R&D projects between 2022-25, focusing on high-potential innovation clusters across three UK regions - Greater Manchester, West Midlands and Glasgow City Region and has been extended by 青瓜视频30m for 2025/26. The programme builds on regional cluster strengths and brings together the innovation ecosystem, to drive economic growth and technological advancement.

The programme is led by Innovate UK, on behalf of UK Research and Innovation (UKRI) and the Department for Science, Innovation and Technology (DSIT) and co-created in Greater Manchester with regional leadership to ensure it is locally led and focused on harnessing the region青瓜视频檚 strengths in high performance materials, health innovation, advanced manufacturing and digital technology.

The IA programme in Greater Manchester provided a unique opportunity to test hypotheses in real-world settings, and those projects emerging from the programme have made significant impacts in just two years. The programme has supported more than 500 businesses to take forward innovations, while over 1000 Greater Manchester residents have accessed skills support 青瓜视频� to either upskill or begin their journey to a career in a high-growth sector.

The work delivered has been highly output-focused, resulting in the creation of meaningful networks and lasting relationships. Partners and stakeholders have embarked on a collective learning journey, creating something new that they can be proud of whilst adding tangible value to a new paradigm shift in ways of working. An approach that has proven to be highly effective in bringing together diverse stakeholders, while strengthening key relationships.

Two years since its launch the projects are demonstrating globally competitive research and development that is putting the region青瓜视频檚 innovation strengths on the map including Advanced Diagnostic Accelerator (ADA)..

ADA has various work streams from public and patient involvement through focus groups to the development of data-driven advanced diagnostics, point-of-care testing and rapid, cost-effective diagnostic tests for conditions like heart failure and lung cancer. By utilising Greater Manchester青瓜视频檚 academic and industry excellence from frontier sectors of Bioinformatics and Genomics, and AI, the project builds on assets already in existence within the city-region青瓜视频檚 ecosystem, including validating and translating biomarkers and therapeutic assets into clinical use.

Key achievements include attracting 青瓜视频2.7m in co-investment to date, the development of a new MedTech product, deployment of new engagement techniques, alongside the identification and creation of at least three new products and services. The programme has strengthened Greater Manchester青瓜视频檚 research, innovation, and data landscape through four submitted grants, two network events, and 26 digital communications assets. It has also expanded access to screening and diagnostic services, engaging over 1200 patients in treatment or research activities, while fostering greater research participation and early diagnosis for underserved communities, with over 400 patients engaged in community events.

By enhancing early diagnosis, boosting business sustainability, and tackling health inequalities, Advanced Diagnostic Accelerator is contributing to increased productivity, reduced economic inactivity due to poor health, and longer life expectancy for Greater Manchester residents and created multiple high value jobs.

Building on this momentum, Health Innovation Manchester, the University of Manchester, Manchester University NHS Foundation Trust and the industry partners have together secured a further 青瓜视频1.6 million Innovate UK grant for the Advanced Diagnostic Accelerator in Greater Manchester.

Science Minister, Lord Vallance, said: 青瓜视频淭he Innovation Accelerator programme is unlocking new opportunities for growth in regions across the UK and this 青瓜视频30m investment backs further collaboration between business, academia and government to build on local innovation that can improve lives across the country.

青瓜视频淕reater Manchester青瓜视频檚 Advanced Diagnostics Accelerator青瓜视频檚 work to support early disease detection and targeted care will support our NHS and with further investment is driving up local jobs, benefiting the local economy and helping to deliver our Plan for Change.青瓜视频�

Andy Burnham, Mayor of Greater Manchester, added: 青瓜视频淚t青瓜视频檚 fantastic to see the innovation happening in Greater Manchester having such a wide-ranging impact. The Advanced Diagnostics Accelerator is improving the diagnosis and treatment of diseases while also delivering a significant economic boost, creating high-value jobs, driving investment, and encouraging closer collaboration between industry and academia. It is also doing great work in getting more of our residents involved in supporting medical trials, and speeding up access to the newest treatments and diagnostics being developed in our universities and research hospitals.

青瓜视频淭he wider Innovation Accelerator programme has been an important catalyst for locally led innovation, and we青瓜视频檝e seen that translate into business growth, new jobs and investment, and advances in technology across a range of sectors. The extension of funding for Greater Manchester青瓜视频檚 10 projects will help them build on the success they青瓜视频檝e already achieved.青瓜视频�

Professor Ben Bridgewater, Chief Executive at Health Innovation Manchester, commented: 青瓜视频淭he investment we have received from the Innovation Accelerator programme for Advanced Diagnostic Accelerator was a catalyst to progress in our mission for improved population health. For each of our focus areas from liver disease and lung cancer to heart failure and chest pain we had a shared ethos to reduce inequalities, build on assets in existence and drive productivity through collaboration. To reach over 1,200 patients, create high-value jobs and establish a spin out in just two years shows the potential of projects like ours to make a meaningful impact on health outcomes.青瓜视频�

The Innovation Accelerator programme has helped to catalyse transformative innovation projects and bolster the UK青瓜视频檚 global competitiveness. For more information and find out about other projects that have been funded through the programme, visit the website.

Published in the journal, , scientists have developed an advanced sensor that can detect volcanic gases with rapid speed and precision.

Using the sensor mounted on a helicopter, the research team measured emissions at Soufri猫re Hills Volcano on the Caribbean Island of Montserrat, revealing that the volcano emitted three times more CO₂ than earlier studies had estimated.

Scientists typically monitor volcanic emissions by focusing on hot vents, known as fumaroles, which release high concentrations of easily detectable acid gases like sulphur dioxide (SO鈧�) and hydrogen chloride (HCl). However, many volcanoes also have cooler fumaroles, where water-rich hydrothermal systems on the volcano absorb the acidic gases, making them harder to detect. As a result, CO鈧� emissions from these cooler sources are often overlooked, leading to significant underestimations in volcanic gas output.

The new technology exposes those hidden emissions, offering a more accurate quantification of the volcanoes gas output.

The findings also have significant implications for volcano monitoring and eruption forecasting.

, lead researcher from The University of Manchester, said: 青瓜视频淰olcanoes play a crucial role in the Earth's carbon cycle, releasing CO鈧� into the atmosphere, so understanding the emissions is crucial for understanding its impact on our climate. Our findings demonstrate the importance of fast sampling rates and high precision sensors, capable of detecting large contributions of cooler CO₂-rich gas.

青瓜视频淗owever, it青瓜视频檚 also important to realise that despite our findings that CO₂ emissions could be around three times higher than we expected for volcanoes capped by hydrothermal systems, volcanoes still contribute less than 5% of global CO₂ emissions, far less than human activities such as fossil fuel combustion and deforestation.青瓜视频�

and co-author, added: 青瓜视频淒evelopment of high-sensitivity high-frequency magmatic gas instruments opens up a new frontier in volcanological science and volcano monitoring. This work demonstrates the new discoveries which await us. By capturing a more complete picture of volcanic gas emissions, we can gain deeper insights into magma movement, observe potential signs of impending eruptions and signs that an ongoing eruption might be ending. For the people living near active volcanoes, such advancements could enhance early warning systems and improve safety measures.青瓜视频�

The research was carried out in collaboration with Montserrat Volcano Observatory and the National Institute of Optics, Firenze, Italy. Now, the study team are searching for funding to make this instrument suitable for unmanned aerial vehicle platforms, opening up new opportunities for performing delicate gas measurements in challenging and hazardous environments.  

This research has been published in the journal Scientific Advances. 

Full title: Quantification of Low-Temperature Gas Emissions Reveals CO鈧� Flux Underestimates at Soufri猫re Hills Volcano, Montserrat.

DOI:

青瓜视频淭hrough her work, Jackie has foregrounded disability inclusion, ensuring that disabled staff and students have a voice in shaping a more inclusive culture,青瓜视频� said Vicki Baars, Head of Culture Transformation at Culture Shift. 青瓜视频淪he truly leads by example and lives the principle of 青瓜视频楴othing about us without us青瓜视频� -  her work remains a vital force for creating lasting change at the university.青瓜视频�

New findings from the latest #BeeWell survey highlight the importance of ensuring every young person has access to everyday support in their wider community. This supports the broader Live Well commitment which seeks to tackle inequalities and improve wellbeing for all residents across the city-region.

Since launching in 2021, the #BeeWell programme, a partnership between Greater Manchester Combined Authority (GMCA), the Gregson Family Foundation, The University of Manchester and Anna Freud, has engaged almost 100,000 young people in Greater Manchester to listen to their needs, understand their wellbeing, and drive action to ensure they receive the support they need.

The report highlights areas where Live Well, Greater Manchester青瓜视频檚 innovative vision for a shift in how public services and community organisations collaborate, will play a crucial role in ensuring no young person is left behind.

One of the key findings in this year青瓜视频檚 report identified urgent challenges around food insecurity, with one in ten young people reporting that on most days, food in their house didn青瓜视频檛 last and there wasn青瓜视频檛 enough money to buy more.  The survey also found that only one in ten young people are consuming the recommended 5 portions of fruit and vegetables a day.

The #BeeWell Youth Steering Group highlighted the need for greater awareness of how nutrition affects energy levels and wellbeing, alongside increased support for families to make healthy choices.

Mayor of Greater Manchester, Andy Burnham, said:

青瓜视频淭he #BeeWell findings make it clearer than ever why our Live Well ambition is so important. We are listening to young people, and they are telling us that access to support in their neighbourhoods, safe spaces to go, and someone to talk to are vital to their wellbeing.

青瓜视频淭hrough Live Well, we are ensuring that every young person, regardless of their background, can get the help they need to thrive. Wellbeing is everybody青瓜视频檚 business, and Greater Manchester is leading the way in putting young people at the heart of this mission.青瓜视频�

Physical activity among girls also remains a concern with the trend continuing from previous years, with just one in four girls meeting the Chief Medical Officer青瓜视频檚 guideline of one hour of activity per day.

Young people raised concerns about the sports offered in PE, gendered PE kits that make participation uncomfortable, and a lack of access to free and enjoyable activities in the community.

Live Well will work alongside GM Moving, local councils, and community partners to address these challenges, removing barriers to participation and increasing opportunities for young people to stay active.

Hayley Lever, CEO of Greater Manchester (GM) Moving said:

青瓜视频淢ovement, physical activity, and sport is fundamental to young people青瓜视频檚 mental wellbeing.

青瓜视频淭he #BeeWell findings highlight the urgent need to accelerate our collective efforts to make physical activity more accessible, inclusive, and enjoyable for all young people.

青瓜视频淚青瓜视频檓 so proud of #FeelGoodYourWay and how it shines a light on how movement, physical activity, and sport is changing young lives for the better.

青瓜视频淭he right opportunities to move can transform a young person青瓜视频檚 life.青瓜视频�

The survey also identified that while 60% of young people feel like they belong at school, the report found lower levels of school belonging reported among girls and LGBTQ+ young people. It also showed lower scores for Year 10 pupils in metrics including sense of school belonging and feeling hope and optimism, when compared to Year 7s.

This drop-off in wellbeing and hope has been a large driver in the development of the Greater Manchester Baccalaureate (MBacc) which launched this year. The MBacc is transforming technical education in our city-region, supporting all our young people to fulfil their potential and help give them hope for the future.

This year青瓜视频檚 survey introduced new measures on access to trusted adults, revealing that while 75% of young people say they have someone to talk to about their worries, boys are less likely to feel that they have someone to confide in than girls.

The #BeeWell Youth Steering believes that improving feelings of school belonging would have a positive impact on overall wellbeing, including increasing hope and optimism for the future.

Saint, from the #BeeWell Youth Steering Group, said:

青瓜视频淚t is incredibly important that we run #BeeWell surveys so we can accurately determine where young people need more support.

青瓜视频淏y analysing these key headlines, we can target the most significant factors impacting the mental wellbeing of young people and aim for improvements within those areas.

青瓜视频淓very young person should be given the opportunity to flourish and succeed and ensuring this not only provides an environment of safety and belonging for the individual, but will collectively help us progress into a more cohesive and compassionate society in the long run.青瓜视频�

The Live Well ambition aims to tackle these disparities head-on by ensuring every young person has somewhere to go and someone to talk to.

Councillor Mark Hunter, GMCA Portfolio Lead for Young People, said:

青瓜视频淓very young person in Greater Manchester deserves access to great everyday support. The #BeeWell data provides us with the evidence we need to take action青瓜视频攚hether that青瓜视频檚 tackling inequalities in school belonging, increasing access to healthy food, or ensuring young people feel safe and supported in their communities.

青瓜视频淲e want to bring services and communities together to make our vision for Greater Manchester a reality, and we are committed to making a real difference to young people青瓜视频檚 lives across our city region.青瓜视频�

In response to the findings, #BeeWell will work with Greater Manchester青瓜视频檚 ten local authorities to support the development of an action plan to improve young people青瓜视频檚 wellbeing across the city-region.

An event will be held in the coming weeks bringing together young people, schools, and community partners to co-design a plan for action based on the #BeeWell insights.

The Summit reinforced that tackling the inequalities that shape how we age, linked to place, gender, class, race, disability and migration, must be central to age-friendly work. MUARG's ongoing work is crucial in driving research and collaboration to improve the experience of ageing and to build fairer, more inclusive and connected cities for all. 

Learn more about the Manchester Urban Ageing Research Group青瓜视频檚 work in building an age-friendly future by .

Also named as a Fellow is Professor Toni Haastrup, a leading expert in feminist international studies. Her work has explored contemporary Africa-EU relations, feminist foreign policy and the Women, Peace and Security agenda. With over 80 published works, her work seeks to bridge theory and practice, which has led to collaborations with UN agencies and EU institutions. Passionate about inclusion in the sector, Toni is currently chair of the . Her contribution to feminist knowledge in Europe was recognised with an Emma Goldman Award in 2022. She is also a mid-career fellow of the Independent Social Research Foundation.

青瓜视频淚 am deeply honoured to be recognised by the Academy of Social Sciences,青瓜视频� Toni said. 青瓜视频淭his recognition further validates the importance of feminist perspectives within the humanities and social sciences, at a time we are increasingly seeing a backlash within and outside the academy. Yet, this work is essential to addressing some of the most pressing challenges of our time, and I am grateful to the colleagues and collaborators who have supported my work over the years.青瓜视频�

Our final new Fellow is Professor Sophie Woodward, a distinguished sociologist who carries out research into material culture, consumption and everyday life. Sophie is the author of several books including Why Women Wear What They Wear (2007), Blue Jeans: The Art of the Ordinary (2012), Birth and Death: experience, ethics and politics (2020) and Material Methods: Researching and Thinking with Things (2019) who co-directs the , as well as serving as Vice-Director of the National Centre for Research Methods (NCRM). She is also one of the founding editors of the new Journal of Creative Research methods. 

青瓜视频淚 am delighted to be made a Fellow of the Academy of Social Sciences - it is wonderful to receive recognition like this,青瓜视频� said Sophie. 青瓜视频淚 look forward to working with other fellows at a time when the world needs social science methods, perspectives and critiques more than ever. I look forward to continuing to develop critical engagements with methods and the data they can generate and my research into everyday lives.青瓜视频�

青瓜视频淚青瓜视频檓 delighted to welcome these outstanding social scientists to the Academy青瓜视频檚 Fellowship, whose research and practice are helping to develop solutions to pressing societal issues,青瓜视频� said Will Hutton, President of the Academy. 青瓜视频淲e look forward to working with them to further promote the vital role the social sciences play in all areas of our lives.青瓜视频�

The scientists also found slightly less, but still significant levels of microplastics in other organs of both male and female turtles, including the heart, kidney, liver and spleen, as well as skeletal muscle, subcutaneous fat, stomach and intestines.

They studied the bodies of 10 stranded loggerhead sea turtles, recovered by the Oceanogr脿fic Foundation of Valencia, that suffered drowning and exhaustion when they were accidently caught up in commercial fishing nets. 

The findings, published in the journal , could spell disaster for the majestic creatures already found in declining numbers in the world青瓜视频檚 oceans.

It is the first study to show that microplastics from the gut can translocate in sea turtles, opening up the possibility of different organs  especially the reproductive system -  being directly affected.

The scientists believe microplastics may also lead to systemic inflammation  in the animals.

The largest median particle size  of around 25 microns was found in the intestines and fat, and the smallest median particle size  - of around 15 microns was found in the stomach and reproductive organs.

Lead author Leah Costello, a PhD researcher from The University of Manchester was funded under a Biotechnology and Biological Sciences Research Council Doctoral Training Studentship. 

She said: 青瓜视频�Microplastics are a pervasive marine environmental pollutant, on a par with other global threats such as climate change and ozone depletion. 

青瓜视频淥ur study is the first to show direct evidence of the presence of microplastics in the reproductive and other organs of loggerhead sea turtles.

青瓜视频淪ea turtles already face many pressures from human activity and although we have been aware that they ingest plastic throughout their range, the finding of microplastics in almost every tissue sample was quite shocking.

青瓜视频淭hese findings show that even seemingly healthy individuals could be under physiological stress, impacting the reproductive success of vulnerable and recovering populations.青瓜视频�

Foreign microparticles were identified in 98.8% of all samples, of which around 70% were  microplastics. 

Analysis revealed that polypropylene, polyester fibres, and polyethylene were the most common microparticle types. 

Polypropylene is used in include food packaging, clothing, bottle caps, ropes, personal care products, fishing gear and twine. 

Loggerhead turtles are regularly reported to ingest plastic bags  - made from polyethylene -  who misidentify them as  jellyfish and algae. 

Polyester is another dominant microfiber releasing large numbers of microfibres into the oceans and seas. 

And further analysis provided direct visualisation of cotton microfibres embedded in loggerhead heart tissue.

 Three million tonnes of primary microplastics are released into environment every year, with a further 5.3 million tonnes of larger plastic items that can degrade into secondary microplastics over time.

Because plastics can remain in the gut for up to four months in sea turtles, the scientists speculate that microplastics can cross biological barriers from the gut to organs via the circulatory system contributing to a suite of adverse biological effects.

Co-author Professor Holly Shiels from the University of Manchester  added: 青瓜视频淢icroplastic accumulation is likely to be associated with organ damage and toxicity in these incredible marine reptiles that can live for 70 years.

青瓜视频淥f particular concern is the impact on reproduction, with implications on growth, development and viability of offspring which could spell trouble for the stability of these already vulnerable sea turtle populations. 

青瓜视频�However, further studies are required to more broadly assess the biological and health impacts of microplastic on sea turtle reproduction.青瓜视频�

• Images: fibre lodged in sea turtle heart; microplastics found in the turtles; drawing of sea turtle by Eve Boswell 
• Microplastics accumulate in all major organs of the Mediterranean loggerhead sea turtle (Caretta caretta) is published in Marine Environmental Research  

Working in partnership with Manchester University NHS Foundation Trust and Roche, the team developed the project - REVISE-HCC.

The REVISE-HCC project, funded by SBRI Healthcare /NHS England, was established to explore the use of an innovative test for liver cancer, which will help patients access earlier care and potentially save lives.

This project focused on implementing an improved strategy for liver cancer surveillance in patients who are at high risk by using the GAAD algorithm developed by Roche.

GAAD is an accurate test that combines blood tests with gender and age to indicate the presence of HCC (Hepatocellular carcinoma), which is the most common cause of cancer affecting the liver and a leading  cause for cancer-related deaths worldwide. The test is used alongside routine HCC surveillance tests to see how it can benefit patients.

With the  combined purpose to improve the detection rate for this deadly cancer at curable stages and improve the quality of life for these patients, we青瓜视频檙e thrilled to receive this recognition.

Healthcare is rapidly shifting, towards more personalised care that青瓜视频檚 more in tune with patients, embracing digital technologies that enable new possibilities. We青瓜视频檙e excited to be at the forefront of this new class of diagnostic algorithms that our teams are helping to shape.

Programme Manager  Oliver Street said:  青瓜视频淢anchester has some of the highest rates of liver disease and liver cancer in the UK and is a significant healthcare and societal burden. Far too many people are diagnosed too late when curative treatment is not possible.

青瓜视频淲e were thrilled to be recognised at this year青瓜视频檚 HSJ Partnership Awards for our partnership with Roche and Manchester University NHS Foundation Trust that implemented this innovative technology at MFT and allows for more patients with liver cancer to be detected an early stage when their cancer is potentially curable.青瓜视频�

Opening remarks were delivered by Professor Duncan Ivison, President and Vice-Chancellor of The University of Manchester, who spoke about the devolution model in Manchester and how the city is reimagining the architecture of the British state.

The discussion between the Mayor and Mark Morrin from thinktank ResPublica, which launched the pivotal report Devo Max 青瓜视频� Devo Manc in 2014 and organised the event with the University青瓜视频檚 Policy@Manchester team, explored the origins of the role of Mayor of Greater Manchester.

Mr Burnham outlined the initial blueprint for the position and how the role has evolved since he took office. He highlighted how homelessness was one of his priority issues from the outset, and how dealing with these forefront problems paved the way to looking at bigger picture, longer-term issues in the region.

He compared the Greater Manchester Combined Authority (GMCA) to a unified government department and criticised the siloed nature of certain national government institutions. He credited the powerful 青瓜视频榩lace first青瓜视频� nature of Manchester青瓜视频檚 political structure and the abundance of community-led initiatives in the region like Live Well, which focuses on health and wellbeing.

During the discussion, Mr Burnham outlined his bold ambitions for skills development in Greater Manchester and highlighted a wider need to link local labour markets to schools. He also discussed his ultimate aim for an employer-driven, all-age, integrated technical education system and his personal pursuit of a Greater Manchester Baccalaureate qualification.

During the conversation, Mr Burnham noted the contribution universities make to Greater Manchester and how The University of Manchester青瓜视频檚 research helps to influence strategies and policies that make a real difference in people青瓜视频檚 lives.

He also cited the wave of innovation the University has catalysed through initiatives like Unit M, which aims to connect the innovation ecosystem in Manchester and the wider region to accelerate inclusive growth. He also mentioned the University of Manchester青瓜视频檚 partnership with the University of Cambridge, and how Manchester can catalyse economic growth through research and innovation.

Professor Duncan Ivison, President and Vice-Chancellor at The University of Manchester said: 青瓜视频淚t was a pleasure to welcome Mayor Andy Burnham for this timely conversation on the future of devolution in Greater Manchester.

青瓜视频淎ndy青瓜视频檚 vision for the region is inspiring and highlights continuing opportunities to work together - whether that青瓜视频檚 equipping our future workforce with essential skills, or driving inclusive growth through initiatives like Unit M. As we continue developing the University's 2035 strategy, these discussions remind us of the power of collaboration and the positive impact we can make together for our communities.青瓜视频�

Mr Burnham noted how the education system underserves people who choose not to go to university. He appealed to all local businesses and institutions in the region to prepare 45-day work placements for young people, citing how 50% of young people given these placements go on to work for the employer.

Reflecting on the event, Mr Burnham said: 青瓜视频淚t has been a rollercoaster for Greater Manchester over the last 10 years in a really positive way. I believe the changes we will see over the next decade will be even more dramatic than the last, and the architecture of the British state will seismically change too. We are looking back at a decade of above-average growth, and across the city we have worked collaboratively to get to the great place we are now.

青瓜视频淯niversities have been some of our most instrumental partners over the years, helping us to build an intellectual case for our strategy. I look forward to our continued work with The University of Manchester as we look to upskill and develop our talent across the city-region.青瓜视频�

Mark Morrin, Head of Research at ResPublica said: 青瓜视频淕reater Manchester has been at the vanguard of place-based devolution since securing its first breakthrough deal over 10 years ago. Progress has been incremental and there is still some way to go before the depth of powers outlined in our Devo Max 青瓜视频� Devo Manc report are realised; not least fiscal devolution. But the devolution revolution is clearly under way and mayoral authorities are set to be the strategic place makers and power brokers of the future.青瓜视频�

According to their study published today (25/03/25), satisfaction levels were lower in practices that rely more both on telephone appointments and consultations with non-GP staff.

Advanced nurse practitioners, physician associates, practice-based pharmacists and even paramedics, are among the roles who over the past few years have increasingly worked in place of GPs.

The study also theorises that patient satisfaction could increase by 1% when 10 additional face to face GP appointments per 1000 patients per month are added.

The findings are released amid recent changes to Government policy which aims to place more emphasis on non-GP roles to fill gaps in primary care provision.

However, critics of the policy argue that the new roles can be a cheap substitute which blur the lines between doctors and non-doctors.

The study is the first to use national appointment data to investigate the complex relationships between patient satisfaction, access, preference for a specific GP, and support for managing long-term conditions against appointment volume, modality (telephone or face-to-face), and practitioner type.

The data set of over half a million English patients from 5,500 practices was taken from the General Practice Patient Survey (GPPS) and  NHS Digital's practice level appointment data, covering August 2022 to March 2023.

The study found that 69.5% of appointments were face-to-face and 27.2% were on the telephone. Only 29.6% of appointments were face-to-face with a GP and 18.4% were GP telephone appointments.

The researchers also found that practices with a larger amount of telephone consultations had less satisfied patients. This dissatisfaction was still present and decreased only slightly when telephone calls were carried out by GPs, rather than non-GP staff.

The  correlation coefficient between face-to-face appointments and overall satisfaction was 0.096, showing that  practices with a greater percentage of face-to-face appointments were  more likely to have patients with higher overall satisfaction.

However the figure for GP face-to-face appointments was 0.167 showing that GP face-to-face appointments have an even stronger correlation.

The study also found that:

• Practices offering more on the day appointments had reduced satisfaction with access compared to practices that offered appointments days or weeks in advance.
• Greater numbers of appointments of any type with any staff member overall resulted in improved patients satisfaction.
• Greater numbers of GP appointments at a practice were associated with reduced unmet health needs.

Dr Patrick Burch is an academic clinical lecturer at The University of Manchester and a practising GP.

He said: 青瓜视频淭his study of appointments from over 5,500 practices showed that more appointments, particularly with face-to-face with GPs, tended to be associated with more satisfied patients who were better able to meet their health needs.

青瓜视频淲hile telephone and IT assisted appointments have an important role to play in general practice, we would cautiously welcome an overall increase in the proportion of face-to-face consultations.

青瓜视频淯ntil recently, simply employing more GPs was not seen as feasible. However, given six out of 10 job-seeking GPs have to find a vacancy to apply for over the past year, this may now be a potential option.

青瓜视频淲e would also welcome measures that free up GP time to enable more patient appointments.青瓜视频�

He added: 青瓜视频淎 greater proportion of telephone appointments were associated with decreased satisfaction in general, especially when provided by non-doctor roles.

青瓜视频淣on-GP clinicians employed in primary care since 2019 has increased by 21,600 full time equivalent staff members.

青瓜视频淎s primary care funding has not gone up significantly, arguably this cash is now being used to pay other less expensive clinicians rather than GPs.

青瓜视频淭he reasons for the findings behind this study are likely to be complex, but there is undoubtedly an important role for non-GP clinicians in primary care.

青瓜视频淧atient satisfaction is not the only measure of success in general practice but it is important that policy makers take note of the link between patient satisfaction and numbers of appointments with GPs.青瓜视频�

In the paper, appointments were only divided into GP or non-GP, with no other categories used. As a proportion, if one goes up, the other goes down.

The paper What is the relationship between the volume and type of appointments in general practice and patient experience? An observational study of general practice in England is published in the British Journal of General Practice . DOI:

To secure the future of bus services, the expert panel has put forward a series of recommendations including investment in more frequent and reliable buses, long-term funding settlements, a new statutory requirement to provide socially necessary services and continued support for affordable fares.

The panel urged the Transport Select Committee to ensure their report to the Government includes a focus on the 青瓜视频榝our As青瓜视频� - Availability, Accessibility, Affordability, and Acceptability. Without addressing these key issues, they point out that millions of people will continue to face transport-related exclusion.

青瓜视频淏uses are an essential public service, yet too many communities are cut off from the bus network - this needs to change,青瓜视频� said Silviya Barrett from Campaign for Better Transport. 青瓜视频淭he Government must identify gaps in the current network, provide targeted funding to plug those gaps and introduce of a 青瓜视频榖us service guarantee青瓜视频� to ensure all communities have access to a good, affordable and reliable bus service in the future.青瓜视频�

青瓜视频淭here is an urgent need for reform,青瓜视频� added Professor Lucas. 青瓜视频淚f the Government takes action now, we can create a sustainable, well-connected bus network that benefits communities, the economy, and public health.青瓜视频�

The research looks, for the first time, into how to assess the range of ongoing needs after having a brain tumour for young people between 16-39 year olds.

Using a questionnaire designed with the help of nearly 130 patients, detailed information is now going to be gathered from 100 brain tumour survivors as part of their follow-up consultation. Researchers will then assess the impact the survey has on providing personalised care to improve the long-term support after treatment. If this trial improves the experience for patients at The Christie, then the plan is to roll it out at to other hospitals around the UK.

Dr Kate Law, a research fellow and specialist nurse at The Christie and honorary research associate at The University of Manchester, who is leading on the research study known as YOU-CAN said: 青瓜视频淎 third of all childhood cancers are brain tumours and survival is highest for 15 青瓜视频� 39 year olds. Currently there is no assessment tailored specifically for young people with a brain tumour.  We have identified an unmet need, and want to address this to make life better for young brain tumour survivors in the future.

青瓜视频淎t The Christie alone we see approximately 550 patients who were diagnosed with brain cancer as a child or young adult every year on long-term follow-up. What is fantastic is that people are living longer and recovering from brain tumours, but we are aware that often these very determined and resilient young people need help with independent living, forming relationships and friendships, starting a family and managing the emotions associated with the long-term effects of a brain tumour. They want to make the most out of life and we need to support them in doing this.

青瓜视频淚t is hoped that the evidence gathered from the YOU-CAN study will be a step towards a change in clinical practice in the future where every young person has access to a multi-disciplinary team for on-going support after being treated for a brain tumour.

Claudia Laird (27), a children青瓜视频檚 nurse from Burnley in Lancashire was diagnosed with a brain tumour in January 2022 when she was 24. Her tumour was 7cm by 5cm and doctors believed it had been growing in her head for 15 years. Claudia went to the GP several times due to headaches, fatigue, memory loss, hallucinations and sickness. She initially thought she had a virus, but a scan revealed she had an astrocytoma, a form of brain cancer.

青瓜视频淚 was a healthy person, so it was hard at first to get a diagnosis. But when I did, from the scan to surgery was like a whirlwind and I had emergency neurosurgery.  Thankfully the surgeon believed he青瓜视频檇 removed the whole tumour. Now I just go for six-monthly scans. While I feel well physically, and no longer on treatment, you青瓜视频檙e left with psychological trauma and you worry about what will happen if the tumour grows back. You have to pick up your life where you left off but it青瓜视频檚 a 青瓜视频榥ew normal青瓜视频�. Forming relationships is hard and I haven青瓜视频檛 had a partner since all this happened. I青瓜视频檓 not 100 per cent back to where I was, and have some short term memory loss and I can get overwhelmed easily.  Hopefully that will improve in time and the brain can re-learn things. It青瓜视频檚 still quite early days and it青瓜视频檚 still hard for me but I take it day by day.

青瓜视频淚 was discharged two days after surgery and I didn青瓜视频檛 even take any time off work. My mum has been a massive support system, and I don青瓜视频檛 think I青瓜视频檇 be here without her, but having a professional like a support worker you can go to with questions would be so useful. I青瓜视频檝e been writing poetry which has been great therapy. I do a lot of charity work and fundraising to give back and next month I青瓜视频檓 helping with a creative workshop for other young people who have brain injuries. I also do a lot of yoga, pilates and relaxation classes which really help. I青瓜视频檓 enjoying life and see things differently now and appreciate everything so much more than before.青瓜视频�

The application sets out detailed proposals relating to the appearance, landscaping, layout and scale of the scheme, which covers Owens Park, Oak House and Woolton Hall.

It builds on the Outline Planning Permission granted in January 2024.  

The application will now be evaluated by Manchester City Council青瓜视频檚 planning department.

A five-week consultation and engagement exercise was completed throughout December 2024 and early January 2025 to ensure the views of the local community informed the proposals.

The ambitious redevelopment plans include the creation of 3,300 modern, high-quality student bedspaces, along with dedicated amenity space, ancillary residential dwellings and greenspaces. Five distinct neighbourhoods that celebrate local history and character, and a central hub as an anchor and heart of the campus, are features of the scheme.

Commenting on the submission of the Reserved Matters Planning Application, Dr Simon Merrywest, Director for the Student Experience, University of Manchester, said: 青瓜视频淭his is an important milestone in realising our vision for the Fallowfield Campus. The plans and proposals within the Reserved Matters Application reinforce our commitment to providing new and returning students with modern, high-quality accommodation, and will help us to meet the future needs of our student population.青瓜视频�

The project is being delivered by the Viridis Consortium - a partnership consisting of GRAHAM, Equitix and Derwent FM.

The demolition of the Owens Park Tower and surrounding buildings is ongoing.

Enabling works are progressing in preparation for the main construction programme, which will commence in 2026. The phased handover of buildings will allow students to move into their new homes at different points from 2027 through to 2030.

GRAHAM has led the planning process in collaboration with the University of Manchester, architects, Sheppard Robson, and planning consultants, Deloitte.

Neil McFarlane, GRAHAM Project Director for the Fallowfield Campus, said: 青瓜视频淭he planning submission is a further important milestone for the Fallowfield Campus project. It is the culmination of months of challenging work and an intensive programme of engagement with the University, staff, students and the local community. We believe the submitted plans will create an exemplar sustainable campus that will enhance the experience of the University青瓜视频檚 next generation of students.青瓜视频�

Sustainable design and construction are embedded within the proposals. The development will be one of the largest Passivhaus developments in the world 青瓜视频� meaning the buildings will use less energy, promote good indoor air quality and maintain comfortable temperatures year-round.

The development is also targeting BREEAM Excellent certification, a further independent sustainability assessment. The preservation of the mature landscape and enhanced green spaces are embedded within the plans.

Natalia Maximova, Associate Partner at Sheppard Robson Architects, who has managed the design process, said: 青瓜视频淥ur designs are inspired by the site's layers of history and its unique character, providing high-quality student homes and amenities in a rich parkland setting. The proposals rebuild the student community at Fallowfield and create a new generation of sustainable student homes."

Tristan Meredith, Equitix Development Director, added: 青瓜视频淓quitix is committed to delivering best in class solutions with a core focus on sustainability. The submitted plans demonstrate our commitment to sustainable development while providing a world-class living experience for the University of Manchester青瓜视频檚 future students.青瓜视频�

For more information on the Fallowfield Campus redevelopment, please visit: /about/governance/corporate-documents/campus-masterplan/fallowfield-consultation 

A University of Manchester academic has been selected as a member of the UK Young Academy - an interdisciplinary network of early-career professionals and researchers working together to tackle pressing global and local challenges and promote lasting change.

is among 42 emerging leaders from across the UK named as the newest members of the UK Young Academy, who come from a wide range of sectors, with backgrounds in political science, engineering, government, communications and the creative and performing industries, and more.

As a member of the UK Young Academy, will have the opportunity to take action on both local and global issues. Through interdisciplinary projects and working across sectors, the members will bridge gaps, drive innovation, and develop the solutions needed to address critical challenges 青瓜视频� all while advancing their professional development and contributing to a global network of Young Academies focused on achieving positive outcomes.

青瓜视频檚 expertise is in nuclear reaction theories and is particularly interested in working on projects related to physics education, science communication, and supporting early-career researchers from at-risk or underrepresented backgrounds. 

For the first time, a select group of emerging leaders have been chosen for membership in the UK Young Academy through a dedicated route in collaboration with the Council of At-Risk Academics (Cara). At-risk academics from Cara青瓜视频檚 network were invited to apply for membership as part of a UK Young Academy member-led project focused on supporting at-risk early-career researchers across the UK. 

Next week, the newest members of the UK Young Academy will come together for their Induction Day, where they will learn about the UK Young Academy青瓜视频檚 activities and programmes. This will be followed by the third annual All Members青瓜视频� Meeting, marking the first opportunity for this new group to connect with the wider membership. 

Speaking on behalf of the UK Young Academy Membership Selection Committee, Alistair McConnell, said: 青瓜视频淭he solutions to the world青瓜视频檚 most pressing challenges won青瓜视频檛 come from a single field or perspective. We need to bring together expertise and insights from a range of disciplines.

青瓜视频淭oday, we are delighted to welcome our newest members, whose diverse backgrounds and expertise will bring fresh perspectives to the UK Young Academy. These members will have the opportunity to challenge boundaries, make new connections, and work together to develop innovative solutions to the challenges that matter most.

青瓜视频淎s we enter our third year as an organisation, the new members will be able to contribute right from the outset. Through involvement in innovative projects, work programmes, or by ensuring that early-career voices are part of key global and local debates, they青瓜视频檒l be positioned to make a meaningful contribution.青瓜视频� 

The new members take up their posts from 1 April 2025, and membership runs for five years.  

As the honorary chair of creative writing, Lemn will joined by fellow judges John McAuliffe, Professor of Poetry at The University of Manchester and Manchester-based poet and critic, Maryam Hessavi.

The theme for 2025 is 青瓜视频樓喙鲜悠礽ons青瓜视频� and the challenge is simple - write a 青瓜视频榤icro poem青瓜视频� of no more than 280 characters, and submit using the official competition entry form.

Lemn said: 青瓜视频淭he Micropoetry Competition sets a wonderful yet challenging task of translating a theme into a short work of art. It青瓜视频檚 a craft to tell a story in such a manner and I青瓜视频檓 looking forward to reading the 2025 entries, centred around the chosen theme. As someone who published a book of tweets in the form of quatrains, I urge you to pen your poem and enter the competition.青瓜视频�

Entries must be submitted by 23:59 on Saturday 21 June 2025, with winners to be announced by Friday 25 July 2025.

Prizes will be awarded for first place (青瓜视频500) and the two runners-up (青瓜视频250), with a 青瓜视频25 book token for winner of the under-18s category.

Professor of Poetry at The University of Manchester, John McAuliffe, said: "World Poetry Day celebrates all that is fascinating about poetry and its manifold forms. Our Micropoetry Competition explores the art of translating a set theme into a condensed poem that captures attention and shares a story.青瓜视频�

For the full entry details as well as the terms and conditions, 

Catherine steps into the role full-time, having served as Interim CEO over the past year, while also fulfilling her responsibilities as Director of Business Engagement and Knowledge Exchange at The University of Manchester. With a wealth of experience in working with businesses, technology transfer and innovation, she brings a deep commitment to advancing UoMIF青瓜视频檚 mission of identifying and commercialising groundbreaking research to drive social, environmental and economic impact. 

Catherine will be succeeded in her previous role as Director of Business Engagement and Knowledge Exchange by Dr Louise Bates, who joins from her position as Head of Strategic Partnerships at The University of Manchester.

青瓜视频淚 am thrilled to take on this role at such an exciting time for the Innovation Factory,青瓜视频� said Catherine. 青瓜视频淢anchester has a proud and established legacy of pioneering innovation that shapes the world and I am eager to build on that tradition. My goal is to strengthen our partnerships, empower our academics, inventors and researchers, and accelerate the journey from discovery to real-world solutions that benefit society and bolster the UK青瓜视频檚 position as a global leader in innovation.青瓜视频�

The appointment comes at a time when technology transfer offices (TTOs) across the UK are increasingly recognised for their economic contributions. 

A 2023 report highlighted that university spinouts in the UK employ tens of thousands and generate billions in revenue annually, underscoring the critical role of organisations like UoMIF in fostering innovation ecosystems. UoMIF plays a critical role in supporting growth in the region through its spinouts and innovation, and is now perfectly placed to grow and increase the environmental, societal and economic impact that it contributes.

Over the past several years, UoMIF established itself as a vital bridge between academic research and commercial application, supporting the University青瓜视频檚 ambition to create impact through translation of world-class research. Catherine aims to build on this foundation, driving UoMIF towards ambitious goals while reinforcing Manchester青瓜视频檚 historic role as a hub of technological advancement.

Professor Duncan Ivison, President and Vice-Chancellor of The University of Manchester, welcomed the appointment, saying: 青瓜视频淚青瓜视频檓 delighted Catherine is stepping into the role of CEO at the Innovation Factory. Her leadership, creativity, and commitment to bringing our research to life exemplify exactly what we're about as a University. 

"Her appointment will help us accelerate the journey from discovery to real-world impact, ensuring our ideas make a meaningful difference - not just here in Manchester, but nationally and globally. It's an exciting step forward as we continue to push boundaries in research and innovation, and I'm truly looking forward to seeing what she'll achieve.青瓜视频�

Professor Richard Jones, Vice-President, Regional Innovation and Civic Engagement at The University of Manchester, said: 青瓜视频淐atherine青瓜视频檚 leadership comes at a pivotal moment for the Innovation Factory as we seek to amplify Manchester青瓜视频檚 position as an innovation powerhouse for the region and the nation. Her appointment signals our commitment to transforming bold ideas into tangible solutions, fostering a vibrant ecosystem where research fuels regional growth and global breakthroughs. 

"The Innovation Factory, under her guidance, will be a valuable asset to support the University青瓜视频檚 world-class innovators and transformative technologies.青瓜视频�

For more information about the University of Manchester Innovation Factory and its work, please visit www.uominnovationfactory.com.

is Professor of Health Policy and is a GP by background. She leads a team of researchers in the Division of Population Health, Health Services Research and Primary Care at The University of Manchester. Professor Checkland青瓜视频檚 team researches the impact of changes to NHS policy, organisation and management, working closely with policy makers at the Department of Health and Social Care and NHS England to ensure that policy and organisational changes are based upon the best possible evidence.  

Professor Checkland has a particular interest in primary care workforce, working with colleagues across the and to develop an evidence base to support policy in this area. 

is Professor in Health Economics, Lead for the Manchester Centre for Health Economics (MCHE), an applied health economist, and a UK-registered pharmacist.  

Professor Elliott applies an economics perspective to better understand complex healthcare themes (patient safety and adherence, primary care, digital interoperability, diabetes, antibiotic resistance, mental health and dementia) to design effective, sustainable solutions that improve health where there is the greatest unmet need. 

is a Professor of Health Psychology at the University as well as being President of the European Health Psychology Society. Professor French is a behavioural scientist who is interested in developing, evaluating and implementing complex interventions to improve health. His research focusses on cancer screening, prevention of diabetes, cancer and cardiovascular disease in high-risk populations, and effects of changing the built environment. 

The University also celebrates , Professor in Oncology, who has been reappointed as Senior Investigator by the NIHR. 

Professor Kath Checkland said: 青瓜视频淚 was absolutely delighted to have my work for NIHR recognised by this award. My research has benefitted enormously from the financial and practical support provided by NIHR, and I am delighted to have this opportunity to contribute to further to its work.  

Professor Rachel Elliott said: 青瓜视频淚 am very pleased and honoured to have been given the Senior Investigator award. As a Senior investigator, I will expand my leadership in research through continued development of the economics of safety work programme, augmented by my role in NIHR-Greater Manchester-Patient Safety Research Collaboration.  

青瓜视频淚 will enhance public, patient, and community engagement in health economics through expanded training and funded projects, while promoting inclusion in the academic workforce by proactively reaching out to underrepresented professions, regions, and institutions, supported by my role as Post-doctoral Award Chair in the NIHR Academy.青瓜视频� 

Professor David French said: 青瓜视频淚 am delighted to be appointed as an NIHR Senior Investigator, and the opportunities this provides to provide leadership in developing and evaluating complex interventions to promote health, especially those with high reach.青瓜视频� 

The NIHR funds Senior Investigators every year. Those appointed to the role help to guide research capacity development and play a leading role in guiding strategy and tackling challenges in the health and social care landscape.  

The position is awarded to those who make an outstanding leadership contribution to the work of the NIHR. All Senior Investigator appointees receive funding for 4 years to support their research activities while undertaking a senior leadership role for the NIHR. 

Working in partnership with the NHS, universities, local government, and the public, the NIHR funds, enables and delivers world-leading health and social care research that improves people青瓜视频檚 health and well-being and promotes economic growth. 

See the full list of NIHR Senior Investigators .

Read NIHR's news story .

The NGI opened in 2015 and became the home of research into the world青瓜视频檚 thinnest, strongest, and most conductive material. Since then, the institute has established itself as a global leader in the research and development of graphene and other advanced 2D materials.  

Through the translation of graphene science into tangible, real world applications, the NGI has provided the opportunity for researchers and industry to work together on a variety of potential applications. The institute has been at the forefront of numerous pioneering projects that have reshaped industries and set new benchmarks for innovation. 

The NGI青瓜视频檚 community of leading academics has played a pivotal role in advancing 2D material research, producing some of the most influential and highly cited studies in the field. Their pioneering work has accelerated the transition of graphene from the laboratory to real-world applications, driving innovation at an unprecedented pace. This collective expertise has cemented Manchester青瓜视频檚 position as the global home of graphene, ensuring it remains at the forefront of discovery and innovation. 

One of the many groundbreaking innovations from the NGI is the recent advancement of graphene-based neural technologies, now entering the first phase of human trials. is using graphene-based brain-computer interface therapeutics to improve precision surgery for diseases such as cancer. 

The NGI has also seen the establishment of many high-profile collaborations and spinouts founded by its academics, or as a result of NGI-based research: 

• A collaboration between Inov-8 and the University led to the development of the world青瓜视频檚 first graphene-enhanced running shoes, proven to be 50% stronger and more durable than other running shoes. This demonstrates the potential of graphene to revolutionise performance sportswear. 
• seeks to increase accessibility to clean water and air through 2D-enhanced membranes.  
• is using breakthrough technology to control infrared thermal radiation, which could have applications in aerospace engineering. 
• are designing and building mineral recovery systems from various sources, such as brines, industrial wastewater, and used batteries. 

At the heart of the National Graphene Institute青瓜视频檚 pioneering research is its state-of-the-art 1,500m虏 nanofabrication facility, featuring ISO Class 5 and 6 cleanrooms spread across two floors. This advanced facility is dedicated to the fundamental research of graphene and 2D materials, and the development of cutting-edge devices that harness their exceptional properties. By providing such unique environment for precision research and innovation, the NGI continues to drive breakthroughs that push the boundaries of material science. 

Reflecting on the anniversary, Professor Vladimir Fal青瓜视频檏o, Director of the National Graphene Institute said: 青瓜视频淭his 10-year milestone is a testament to the NGI青瓜视频檚 relentless pursuit of excellence and the collaborative spirit that has defined our journey. 

青瓜视频淲e are immensely proud of the tangible impact our research has had across multiple sciences and industries and remain excited about harnessing 2D materials青瓜视频� potential to address some of the world青瓜视频檚 most pressing challenges.青瓜视频�  

Looking ahead, the NGI is committed to furthering its legacy of groundbreaking research and sustaining the pipeline of innovation together with its sister institute, the (GEIC), and the nurturing of the next generation of 2D materials scientists with the PhD programme. 

Innovative research remains at the forefront of the NGI青瓜视频檚 mission, with the Institute currently exploring green hydrogen technologies, next-generation batteries and supercapacitors for faster AI and machine learning, advanced quantum electronics, and the continued development of research into nanofluidics, nanocomposites, and van der Waals materials.  

The most recent statistics show that violence against women and girls affects one in 12 women in . A quarter of domestic abuse incidents reported to police involve known, repeat perpetrators. But despite being to identify and control the most serious perpetrators, police do not currently have systems good enough to do that.

Currently, police forces use an algorithm to determine which offenders pose the greatest risk to women and girls. This is known as the 青瓜视频� perpetrators are propelled up or down a list based on the recency, frequency, gravity (seriousness) of reported incidents, and the vulnerability of the victim.

The gap in this approach is that it largely treats incidents as isolated, when they should be looked at as a whole. Research has also found it is used between forces.

Most police perpetrator lists contain hundreds or even thousands of people, making them difficult tools to use. They also do not seem to be able to distinguish who the most serious offenders are, with men with very similar profiles near the top, middle and bottom of the lists.

We propose an , which would assess the whole of a perpetrator青瓜视频檚 record of incidents. This would allow police to identify not only the most dangerous perpetrators, but also opportunities to better address their offending earlier on. This might be with diversion to programmes designed to support better choices and rehabilitation, or arrest and incarceration to prevent them harming other people.

By joining together incidents recorded by police for individual perpetrators, we constructed detailed case studies using police officer青瓜视频檚 notes. Here is a summary of two people who appear in one force青瓜视频檚 perpetrator list.

1. Male born mid 1980s, involved in 340 incidents over 20 years

His offending begins with an indecent assault on a young teenage girl when he is 19. He is increasingly involved in drug-related offending in his 20s. He is later sentenced to six years in jail for arson endangering life. Released on conditional licence, he is re-convicted of the harassment of his ex-partner and recalled to prison.

Release is followed by further offences until the mid-2010s when he is imprisoned again. When released, his offending is erratic (low-level public order, violence, threats, drug-related offending).

Throughout his 30s, he frequently victimises partners and ex-partners. He has no settled address and is homeless at various points of his life. He is still subject to frequent mental health episodes.

2. Male born early 1980s, involved in 396 incidents over 25 years

In his teens he was involved in low-level thefts, criminal damage and breaches of an antisocial behaviour order. He was also suspected of selling drugs to schoolchildren, and imprisoned, aged 18, for drug-related violence.

In his 20s he 青瓜视频渁ssociates with青瓜视频� children and is found with a missing vulnerable schoolgirl hiding in his house. He continues to commit offences of criminal damage, drug dealing, and stealing vehicles. Another missing teenage girl is found to be living with him.

In his early 20s he very violently assaults and harasses much younger partners. He continues to commit public order offences and to threaten, harass, and assault current and ex-partners, kicking his pregnant partner in the stomach.

In the early 2020s, police attend his ex-partner青瓜视频檚 house following abandoned 999 calls 青瓜视频� they find him with his hand over her mouth to stop her calling out to the police. He continues to be violent to ex-partners and his involvement in drug-related offending deepens. He is currently in prison for a violent offence.

Who is the danger?

Both men pose a real and severe threat of violence to women and girls as well as the public. But the RFGV algorithm places the first man more than a thousand places higher than the second. Clearly treating the offences they commit in isolation is not sufficient to distinguish which man poses the greatest risk.

A life-course approach, which takes into account the type and pattern of offending as it develops over time, is less susceptible to fluctuations which move an offender rapidly up or down the priority lists. Therefore, it more reliably reflects who poses the greatest risk.

A better ranking system is clearly required. The RFGV algorithm provides a 青瓜视频渟core青瓜视频�, but a more sophisticated system would also evaluate the direction of offending of individuals 青瓜视频� is it escalating, more frequent, more serious?

A life-course approach could be used separately or together with RFGV to allow police analysts to identify the most serious perpetrators. It may also be possible to use artificial intelligence to identify trends in offending and escalation of risk through analysis of thousands of police incident reports in real time.

The system could then identify opportunities for which have been shown to be effective in reducing re-offending against current and future victims. It could also automatically trigger warnings to neighbourhood officers, specialist domestic abuse-trained officers, mental health services and so on.

We won青瓜视频檛 really know the full capability until new systems are tried, and evaluated. This also means including the voices of survivors and focusing on the lives of persistent perpetrators 青瓜视频� often substance use, homelessness, estrangement, imprisonment and mental health problems are at play. The possibilities of learning from artificial intelligence or other technology should not be privileged over the very sources of the data such intelligence relies upon: victims青瓜视频� experiences.

, Professor of Criminology, and , Professor of Social Justice,  
This article is republished from under a Creative Commons license. Read the .